Research Paper Volume 15, Issue 10 pp 4363—4373

Figure 3. Role of PCSK6 in Th1 cell differentiation. (A, B) FCM (n=3). The proportion of Th1 cells did not show significant difference in Control vs. NC groups, that in PCSK6-OV group significantly increased relative to Control group, and that of PCSK6-Si group decreased relative to Control group. ^*P<0.05 in relative to Control group, ^#P<0.05 in relative to NC group. (C) ELISA (n=3). IL-2, TNF-α and IFN-γ contents of PCSK6-OV group significantly increased relative to those in Control group, but their contents of PCSK6-Si group decreased relative to Control group. ^*P<0.05 vs. Control group, ^#P<0.05 vs. NC group. (D, E) Relative protein expression levels (n=3). p-STAT1 and T-bet contents of PCSK6-OV group increased, while p-STAT1 level decreased in PCSK6-Si group, with significant difference relative to Control group. ^*P<0.05 vs. Control group, ^#P<0.05 vs. NC group.