Construction and experimental validation of a B cell-related gene signature to predict the prognosis and immunotherapeutic sensitivity in bladder cancer

Ranran Zhou; Jiawei Zhou; Bahaerguli Muhuitijiang; Xiangbo Zeng; Wanlong Tan

doi:doi:10.18632/aging.204753

← Back

Research Paper

Construction and experimental validation of a B cell-related gene signature to predict the prognosis and immunotherapeutic sensitivity in bladder cancer

Figure 2. B cells’ prognosis value in BLCA. (A) The dual roles of B cells in tumor immunity. (B) The B cells’ infiltration level was a predictor for OS in the TCGA-BLCA cohort. (C) The predictive ability of B cells’ infiltrating proportion to immunotherapeutic sensitivity. (D) B cell number in each BLCA specimen was quantified using CD20 staining. (E) The B cell counts of the patients form the NH cohort. (F) The survival statuses and follow-up duration of the patients in the NH cohort. (G) High infiltration level of B cells heralded favorable prognosis in the NH cohort. (H–J) The comparison of the predictive ability of B cell number and routine clinicopathological traits to 6- (H), 12- (I), and 12-months’ OS (J). BLCA, bladder cancer; OS, overall survival.