MCF2L-AS1 promotes the biological behaviors of hepatocellular carcinoma cells by regulating the miR-33a-5p/FGF2 axis

Hongliang Ou; Yunsong Qian; Li Ma

doi:doi:10.18632/aging.

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Research Paper

MCF2L-AS1 promotes the biological behaviors of hepatocellular carcinoma cells by regulating the miR-33a-5p/FGF2 axis

Figure 4. miR-33a-5p was a potential target of MCF2L-AS1. (A) The potential miRNA targets of lncRNA MCF2L-AS1 were predicted through two online databases, including ENCORI (https://starbase.sysu.edu.cn/) and lncBase V.3 (https://diana.e-ce.uth.gr/lncbasev3). The common miRNAs were analyzed via Venny’s diagram. (B) The binding sites of the two miRNAs on MCF2L-AS1 were shown. (C) The MCF2L-AS1 downregulation model was constructed. (D, E) MCF2L-AS1, miR-33a-5p and miR-138-5p levels were gauged via qRT-PCR. (F) The miR-33a-5p level in liver hepatocellular carcinoma (LIHC) tissues from the TCGA database were analyzed via ENCORI (https://starbase.sysu.edu.cn/). (G, H) K-M plotter evaluated the relationship between the miR-33a-5p level and the overall survival of LIHC patients.