Research Paper

Figure 1. High expression of hyperphosphorylated tau and total tau was found in P301S Tau mice from early ages. (A, C) Representative Western blots showing ^S202/T205p-tau, ^S214p-tau and total tau in PFC (A) and Hippocampus (C) of WT vs. P301S transgenic mice (WT: n = 3, P301S: n = 4) at 1 month to 6 months of age. (B, D) Plots of quantification data of ^S202/T205p-tau, ^S214p-tau and total tau (normalized to GAPDH) in PFC (B) and Hippocampus (D) of WT vs. P301S mice at various ages. At each time point, ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001, t-test.