Research Paper
Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model
Figure 5. Gene expression profiling revealed various pattens of changes in PFC and hippocampus of P301S mice at different ages. (A–I) Bar graphs of mRNA levels in PFC and hippocampus of WT and P301S mice at 3 and 9 months (n: WT/Tau = 6/6 per group), which included: Category 1 (UP-DOWN) (A–D, Nlgn1, Wnt7a, Syp, Stx1b); Category 2 (NO-DOWN) (E, F, Shank3, Snap25); Category 3 (NO-UP) (G, H, Rab34, Rab5a); and Category 4 (NO CHANGE) (I, Vamp2). #p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001, t-test.