Research Paper Volume 3, Issue 3 pp 262—276

RasGrf1 deficiency delays aging in mice


Figure 2. Increased Neuromuscular Coordination Coincided With Biomarkers of Aging in RasGrf1−/− Mice. (A) Neuromuscular coordination was quantified as the percentage of male mice that successfully passed the tightrope test. Numbers within the bars indicate animals that passed the test divided by the total number of animals which were subjected to the test. Young animals were 4-6 months old, and old animals were 20-22 months old. Significance is shown as *p<0.05; **p<0.01 vs. WT. (B) Liver extracts from male mice were used to assess 16S rRNA expression in 4-6 months old animals. Expression of 16S rRNA was significantly higher in RasGrf1−/− mice. WT n = 4; RasGrf1−/− = 3; *p=0.03.