Research Paper Volume 3, Issue 3 pp 262—276

Figure 6. Schematic Representation of the Molecular and Physiological Characteristics of RasGrf1^−/− Animals. RasGrf1−/− results in an increased longevity which is mediated by a lower insulin /IGF signaling (IIS) which eventually leads to metabolic benefits and in lower ROS production and subsequent oxidative protection. These two independent changes converge in a notable increase in longevity and fitness.