Research Perspective Volume 3, Issue 10 pp 913—919

Figure 3. A schematic illustration of the pathways linking caloric restriction, Insulin/IGF, PI-3K/AKT and NF-κB signalling (adapted from Salminen and Kaarniranta [16] and Chauncey et al. [48]). Sustained insulin/IGF signalling promotes NF-κB signalling by activation of PI-3K/AKT pathway whereas caloric restriction (CR) reduces NF-κB signalling by dampening PI-3K/AKT and increasing expression of SIRT1. The PI3K/AKT and NF-κB pathways are also reportedly linked via RIP1.