Research Paper Volume 4, Issue 7 pp 462—479

Figure 6. The methylated K271 peptide does not bind to kown methyl-lysine binding domains.

Twenty-one amino acid peptides surrounding K271, either mono-methylated (left) or unmethylated (right) were incubated with potential methyl-lysine and acetyl-lysine binding domains on a protein array. GST-Alexa Fluor 555 is used as a positive control. A detailed description of the binding domains present on the protein array is provided in the lower panels.