MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in <i>C. elegans</i>

Michèle Riesen; Inna Feyst; Nattaphong Rattanavirotkul; Marina Ezcurra; Jennifer M.A. Tullet; Irene Papatheodorou; Matthias Ziehm; Catherine Au; Ann F. Gilliat; Josephine Hellberg; Janet M. Thornton; David Gems

doi:doi:http://dx.doi.org/10.18632/aging.100638

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Research Paper Volume 6, Issue 2 pp 98—117

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

Figure 4. Effects of mdl-1 on aging.

(A) Effects of mdl-1(tm311) on lifespan (for statistics, see Table S1, combined data). (B) Effect of mdl-1 on age-specific mortality profiles. (C, D) Mortality analysis using logistic model. (C) Estimated values of logistic model parameters. (D) Probability, p, of parameters in compared genotypes being the same, holding other parameters constant.