MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in <i>C. elegans</i>

Michèle Riesen; Inna Feyst; Nattaphong Rattanavirotkul; Marina Ezcurra; Jennifer M.A. Tullet; Irene Papatheodorou; Matthias Ziehm; Catherine Au; Ann F. Gilliat; Josephine Hellberg; Janet M. Thornton; David Gems

doi:doi:http://dx.doi.org/10.18632/aging.100638

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Research Paper Volume 6, Issue 2 pp 98—117

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

Figure 5. No effect of uterine tumors on lifespan.

(A) Uterine tumors are not seen in glp-4(bn2) mutants (raised at 15°C to L4 then shifted to 25°C). Uterine classes 2-5 indicate presence of tumors. Each dot corresponds to a uterine status measurement. (B) glp-4 does not suppress mdl-1 effects on lifespan (for statistics, see Table S2, trial 1). (C) FUdR suppresses formation of uterine tumors at 50μM or greater. Stars represent a significant difference to worms of the same genotype in the absence of FUdR. No significant difference in tumor levels between N2 and mdl-1 were detected at this age at any FUdR concentration. * 0.01 < p < 0.05; ** 0.001 < p < 0.01; *** p < 0.001 (Wilcoxon Mann test). (D) 50μM FUdR does not suppress mdl-1 shortevity or increase N2 lifespan (for statistics, see Table S2, trial 1). (E) Effect of mdl-1 on glp-4 longevity (for statistics, see Table S2, trial 2).