Research Paper Volume 6, Issue 2 pp 98—117
MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans
Figure 7. Extent of loss of Myc, Tsc1/Tsc2 and 4E-BP among the Nematoda.
(A) Outline of missing elements of Tor and Myc/Max/Mad pathways in C. elegans. Green, tumor-suppressor/anti-aging; orange, oncogene/pro-aging. In brackets, proteins missing from C. elegans. (B) Presence and absence of Myc, Tsc1, Tsc2 and 4E-BP among nematodes and platyhelminths. Red, absent; dark blue, present; pink, not found; pale blue, putative but somewhat divergent 4E-BP. Not found: a caveat to this analysis may be the incompleteness of the genomic sequences of some of these species with draft assemblies being available for G. pallida and H. contortus and only contigs available for T.muris. (C) Phylodendrograms of Tsc1 and Tsc2 sequences for nematodes and other animal groups. Note that species and sequence phylogenies correspond.