Research Paper Volume 6, Issue 10 pp 856—872

Figure 5. Network and enrichment analysis of age-associated altered proteins using Gene Ontology categories for biological processes.

For the 43 age-associated altered proteins, a total of 71 unique biological processes were identified as highly enriched (p ≤ 0.01). Different p-values are color coded as follows: p < 0.0005 (black), p = 0.0005-0.005 (deep red), p = 0.005-0.01 (bright red). Proteins were color coded according to their regulation profile: increasing (yellow) and decreasing (blue). Terms describing a similar biological process were grouped according to GO slim categories. A total of eight main categories of GO terms were identified: proteostasis (8 proteins), response to stimuli and stress (9 proteins), development and differentiation (7 proteins), cell organization (15 proteins), cell communication and signal transduction (13 proteins), RNA metabolism (17 proteins), cell cycle and proliferation (25 proteins) and cell death (13 proteins).