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Research Paper Volume 7, Issue 4 pp 223—232

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity

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Figure 5.

Effects of wortmannin on glucose of Ppp2cαloxp/loxp: Alb and WT: Alb mice. (a) GTT and AUC of over fasted Ppp2cαloxp/loxp: Alb and WT: Alb mice treated with wortmannin lasted 4weeks. (b) Immunoblot analysis with antibodies to Akt, phosphor-Akt (pSer473 and pThr308) was examined in Ppp2cαloxp/loxp: Alb and WT: Alb mice after injection with saline or insulin after 4 weeks wortmannin treatment. Data were analysed by two-tailed Student's t test (*p < 0.05).