Volume 7, Issue 4

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Beuselinck B, Fridman WH, Zucman-Rossi J, . Molecular subtypes and prognosis in RCC. . 7:219-220. https://doi.org/10.18632/aging.100736

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Provider: TY - JOUR AU - Beuselinck, Benoit AU - Fridman, Wolf Herman AU - Zucman-Rossi, Jessica TI - Molecular subtypes and prognosis in RCC JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100736 DO - 10.18632/aging.100736 SP - 219 EP - 220 PY - ER -

Provider: TY - JOUR AU - Beuselinck, Benoit AU - Fridman, Wolf Herman AU - Zucman-Rossi, Jessica TI - Molecular subtypes and prognosis in RCC JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100736 DO - 10.18632/aging.100736 SP - 219 EP - 220 PY - AB - ER -

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Shen Y, Liao D, Cao D, . AKR1B10 in gastrointestinal diseases. . 7:221-222. https://doi.org/10.18632/aging.100737

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Provider: TY - JOUR AU - Shen, Yi AU - Liao, Duan-Fang AU - Cao, Deliang TI - AKR1B10 in gastrointestinal diseases JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100737 DO - 10.18632/aging.100737 SP - 221 EP - 222 PY - ER -

Provider: TY - JOUR AU - Shen, Yi AU - Liao, Duan-Fang AU - Cao, Deliang TI - AKR1B10 in gastrointestinal diseases JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100737 DO - 10.18632/aging.100737 SP - 221 EP - 222 PY - AB - ER -

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Xian L, Hou S, Huang Z, Tang A, Shi P, Wang Q, Song A, Jiang S, Lin Z, Guo S, Gao X, . Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity. . 7:223-232. https://doi.org/10.18632/aging.100725

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Provider: TY - JOUR AU - Xian, Li AU - Hou, Siyuan AU - Huang, Zan AU - Tang, An AU - Shi, Peiliang AU - Wang, Qinghua AU - Song, Anying AU - Jiang, Shujun AU - Lin, Zhaoyu AU - Guo, Shiying AU - Gao, Xiang TI - Liver-specific deletion of <i>Ppp2cα</i> enhances glucose metabolism and insulin sensitivity JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100725 DO - 10.18632/aging.100725 SP - 223 EP - 232 PY - ER -

Provider: TY - JOUR AU - Xian, Li AU - Hou, Siyuan AU - Huang, Zan AU - Tang, An AU - Shi, Peiliang AU - Wang, Qinghua AU - Song, Anying AU - Jiang, Shujun AU - Lin, Zhaoyu AU - Guo, Shiying AU - Gao, Xiang TI - Liver-specific deletion of <i>Ppp2cα</i> enhances glucose metabolism and insulin sensitivity JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100725 DO - 10.18632/aging.100725 SP - 223 EP - 232 PY - AB - Protein phosphatase 2A (PP2A) is a key negative regulator of phosphatidylinositol 3-kinase/Akt pathway. Previous study showed that, in the liver, the catalytic subunit of PP2A (PP2Ac) is closely associated with insulin resistance syndrome, which is characterized by glucose intolerance and dyslipidemia. Here we studied the role of liver PP2Ac in glucose metabolism and evaluated whether PP2Ac is a suitable therapeutic target for treating insulin resistance syndrome. Liver-specific Ppp2cα knockout mice (Ppp2cαloxp/loxp: Alb) exhibited improved glucose homeostasis compared with littermate controls in both normal and high-fat diet conditions, despite no significant changes in body weight and liver weight under chow diet. Ppp2cαloxp/loxp: Alb mice showed enhanced glycogen deposition, serum triglyceride, cholesterol, low density lipoprotein and high density lipoprotein, activated insulin signaling, decreased expressions of gluconeogenic genes G6P and PEPCK, and lower liver triglyceride. Liver-specific Ppp2cα knockout mice showed enhanced glucose homeostasis and increased insulin sensitivity by activation of insulin signaling through Akt. These findings suggest that inhibition of hepatic Ppp2cα may be a useful strategy for the treatment of insulin resistance syndrome ER -

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Novelle MG, Davis A, Price NL, Ali A, Fürer-Galvan S, Zhang Y, Becker K, Bernier M, de Cabo R, . Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo. . 7:233-240. https://doi.org/10.18632/aging.100732

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Provider: TY - JOUR AU - Novelle, Marta G. AU - Davis, Ashley AU - Price, Nathan L. AU - Ali, Ahmed AU - Fürer-Galvan, Stefanie AU - Zhang, Yongqing AU - Becker, Kevin AU - Bernier, Michel AU - de Cabo, Rafael TI - Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both <i>in vitro</i> and <i>in vivo</i> JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100732 DO - 10.18632/aging.100732 SP - 233 EP - 240 PY - ER -

Provider: TY - JOUR AU - Novelle, Marta G. AU - Davis, Ashley AU - Price, Nathan L. AU - Ali, Ahmed AU - Fürer-Galvan, Stefanie AU - Zhang, Yongqing AU - Becker, Kevin AU - Bernier, Michel AU - de Cabo, Rafael TI - Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both <i>in vitro</i> and <i>in vivo</i> JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100732 DO - 10.18632/aging.100732 SP - 233 EP - 240 PY - AB - Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, better protection against heat shock and other genotoxic insults have helped explain the pro-survival properties of CR. In this study, both in vitro and in vivo responses to heat shock were investigated using two different models of CR. Murine B16F10 melanoma cells treated with serum from CR-fed rats showed lower proliferation, increased tolerance to heat shock and enhanced HSP-70 expression, compared to serum from ad libitum-fed animals. Similar effects were observed in B16F10 cells implanted subcutaneously in male C57BL/6 mice subjected to CR. Microarray analysis identified a number of genes and pathways whose expression profile were similar in both models. These results suggest that the use of an in vitro model could be a good alternative to study the mechanisms by which CR exerts its anti-tumorigenic effects. ER -

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Do A, Menon V, Zhi X, Gesing A, Wiesenborn DS, Spong A, Sun L, Bartke A, Masternak MM, . Thyroxine modifies the effects of growth hormone in Ames dwarf mice. . 7:241-255. https://doi.org/10.18632/aging.100739

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Provider: TY - JOUR AU - Do, Andrew AU - Menon, Vinal AU - Zhi, Xu AU - Gesing, Adam AU - Wiesenborn, Denise S. AU - Spong, Adam AU - Sun, Liou AU - Bartke, Andrzej AU - Masternak, Michal M. TI - Thyroxine modifies the effects of growth hormone in Ames dwarf mice JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100739 DO - 10.18632/aging.100739 SP - 241 EP - 255 PY - ER -

Provider: TY - JOUR AU - Do, Andrew AU - Menon, Vinal AU - Zhi, Xu AU - Gesing, Adam AU - Wiesenborn, Denise S. AU - Spong, Adam AU - Sun, Liou AU - Bartke, Andrzej AU - Masternak, Michal M. TI - Thyroxine modifies the effects of growth hormone in Ames dwarf mice JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100739 DO - 10.18632/aging.100739 SP - 241 EP - 255 PY - AB - Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early‐life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male dwarfs with GH + T4 between the ages of 2 and 8 weeks rescued somatic growth yet did not reduce lifespan to match normal controls, thus contrasting with the previously reported effects of GH alone. While the male dwarf GH + T4 treatment group had no significant effect on lifespan, the female dwarfs undergoing treatment showed a decrease in maximal longevity. Expression of genes related to GH and insulin signaling in the skeletal muscle and white adipose tissue (WAT) of female dwarfs was differentially affected by treatment with GH + T4 vs. GH alone. Differences in the effects of GH + T4 vs. GH alone on insulin target tissues may contribute to the differential effects of these treatments on longevity. ER -

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van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PP, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DP, Heeringa P, . High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. . 7:256-268. https://doi.org/10.18632/aging.100738

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Provider: TY - JOUR AU - van der Heijden, Roel A AU - Sheedfar, Fareeba AU - Morrison, Martine C AU - Hommelberg, Pascal PH AU - Kor, Danny AU - Kloosterhuis, Niels J AU - Gruben, Nanda AU - Youssef, Sameh A AU - de Bruin, Alain AU - Hofker, Marten H AU - Kleemann, Robert AU - Koonen, Debby PY AU - Heeringa, Peter TI - High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100738 DO - 10.18632/aging.100738 SP - 256 EP - 268 PY - ER -

Provider: TY - JOUR AU - van der Heijden, Roel A AU - Sheedfar, Fareeba AU - Morrison, Martine C AU - Hommelberg, Pascal PH AU - Kor, Danny AU - Kloosterhuis, Niels J AU - Gruben, Nanda AU - Youssef, Sameh A AU - de Bruin, Alain AU - Hofker, Marten H AU - Kleemann, Robert AU - Koonen, Debby PY AU - Heeringa, Peter TI - High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100738 DO - 10.18632/aging.100738 SP - 256 EP - 268 PY - AB - Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver are both prone to become chronically inflamed with prolonged obesity, their individual contribution to the development of metabolic inflammation remains speculative. Thus, we aimed to elucidate the sequence of inflammatory events in adipose and hepatic tissues to determine their contribution to the development of metabolic inflammation and insulin resistance (IR) in diet-induced obesity. To confirm our hypothesis that adipose tissue (AT) inflammation is initiated prior to hepatic inflammation, C57BL/6J male mice were fed a low-fat diet (LFD; 10% kcal fat) or high-fat diet (HFD; 45% kcal fat) for either 24, 40 or 52 weeks. Lipid accumulation and inflammation was measured in AT and liver. Glucose tolerance was assessed and plasma levels of glucose, insulin, leptin and adiponectin were measured at various time points throughout the study. With HFD, C57BL/6j mice developed a progressive obese phenotype, accompanied by IR at 24 and 40 weeks of HFD, but IR was attenuated after 52 weeks of HFD. AT inflammation was present after 24 weeks of HFD, as indicated by the increased presence of crown-like structures and up-regulation of pro-inflammatory genes Tnf, Il1β, Mcp1 and F4/80. As hepatic inflammation was not detected until 40 weeks of HFD, we show that AT inflammation is established prior to the development of hepatic inflammation. Thus, AT inflammation is likely to have a greater contribution to the development of IR compared to hepatic inflammation. ER -

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Noce A, Canale MP, Capria A, Rovella V, Tesauro M, Splendiani G, Annicchiarico-Petruzzelli M, Manzuoli M, Simonetti G, Di Daniele N, . Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients. . 7:269-279. https://doi.org/10.18632/aging.100740

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Provider: TY - JOUR AU - Noce, Annalisa AU - Canale, Maria Paola AU - Capria, Ambrogio AU - Rovella, Valentina AU - Tesauro, Manfredi AU - Splendiani, Giorgio AU - Annicchiarico-Petruzzelli, Margherita AU - Manzuoli, Micol AU - Simonetti, Giovanni AU - Di Daniele, Nicola TI - Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100740 DO - 10.18632/aging.100740 SP - 269 EP - 279 PY - ER -

Provider: TY - JOUR AU - Noce, Annalisa AU - Canale, Maria Paola AU - Capria, Ambrogio AU - Rovella, Valentina AU - Tesauro, Manfredi AU - Splendiani, Giorgio AU - Annicchiarico-Petruzzelli, Margherita AU - Manzuoli, Micol AU - Simonetti, Giovanni AU - Di Daniele, Nicola TI - Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients JO - JA - VL - 7 IS - 4 PB - SN - UR - https://doi.org/10.18632/aging.100740 DO - 10.18632/aging.100740 SP - 269 EP - 279 PY - AB - Vascular calcifications are frequent in chronic renal disease and are associated to significant cardiovascular morbidity and mortality. The long term predictive value of coronary artery calcifications detected by multi-layer spiral computed tomography for major cardiovascular events was evaluated in non-diabetic Caucasian patients on maintenance hemodialysis free of clinical cardiovascular disease. Two-hundred and five patients on maintenance hemodialysis were enrolled into this observational, prospective cohort study. Patients underwent a single cardiac multi-layer spiral computed tomography. Calcium load was quantified and patients grouped according to the Agatston score: group 1 (Agatston score: 0), group 2 (Agatston score 1-400), group 3 (Agatston score 401-1000) and group 4 (Agatston score &gt;1000). Follow-up was longer than seven years. Primary endpoint was death from a major cardiovascular event. Actuarial survival was calculated separately in the four groups with Kaplan-Meier method. Patients who died from causes other than cardiovascular disease and transplanted patients were censored. The “log rank” test was employed to compare survival curves. One-hundred two patients (49.7%) died for a major cardiovascular event during the follow-up period. Seven-year actuarial survival was more than 90% for groups 1 and 2, but failed to about 50% for group 3 and to &lt;10% for group 4. Hence, Agatston score &gt;400 predicts a significantly higher cardiovascular mortality compared with Agatston score &lt;400 (p&lt;0.0001); furthermore, serum Parathyroid hormone levels &gt; 300 pg/l were associated to a lower survival (p &lt; 0.05). Extended coronary artery calcifications detected by cardiac multi-layer spiral computed tomography, strongly predicted long term cardiovascular mortality in non-diabetic Caucasian patients on maintenance hemodialysis. Moreover, it was not related to conventional indices of atherosclerosis, but to other non-traditional risk factors, as serum Parathyroid hormone levels. A full cost-benefit analysis is however necessary to justify a widespread use of cardiac multi-layer spiral computed tomography in clinical practice. ER -

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