Research Paper Volume 8, Issue 12 pp 3241—3254

Figure 1. IGF-BP2 Mediates Age’s Direct Association with Future Dementia Severity, as measured by dEQ. APOE = apolipoprotein e4 status; CFI = Comparative Fit Index; GDS = Geriatric Depression Scale; HCY = serum homocysteine; HgbA1c = serum hemoglobin A1c; IGF-BP2 = Insulin-like Growth Factor Binding Protein 2; RMSEA = Root Mean Square Error of Association.

*All observed variables except AGE are adjusted for APOE, education, ethnicity, gender, GDS, HCY, and HgbA1c (paths not shown for clarity). The covariates are densely intercorrelated.