Research Paper Volume 8, Issue 12 pp 3298—3310
miR-34a is a common link in both HIV- and antiretroviral therapy-induced vascular aging
Figure 2. The effect of miR-34a on the senescence of cultured ECs. (A) The expression of miR-34a in ECs was successfully increased by Ad-miR-34a (30 MOI) and decreased by AntagomiR-34a (30 nM). (B) The senescence of ECs as shown by senescence-associated beta-gal staining was significantly inhibited by miR-34a inhibition. In contrast, cell senescence was much exacerbated by miR-34a overexpression. (C) Representative images from beta-gal staining of ECs. (D) Cell proliferation was increased by AntagomiR-34a, but decreased by Ad-miR-34a. Note: n=6; *p<0.05 compared with control groups.