Research Paper Volume 8, Issue 12 pp 3390—3399
Aging promotes neoplastic disease through effects on the tissue microenvironment
Figure 3. Panels (A) and (B) Histochemical staining for DPPIV of liver samples obtained from rats transplanted with pre-neoplastic hepatocytes at young age and killed 8 months after Tx. Small clusters of DPPIV-expressing hepatocytes (orange-rust) were discerned in all animals. Histochemical staining for DPPIV (panel C) and standard H&E staining (panel D) of a large hepatic nodule from a rat transplanted with pre-neoplastic hepatocytes at old age and killed 8 months later. Note the typical appearance of nodular hepatocytes arranged in multiple cell-thick plates. Magnification: 100x.