Research Paper Volume 8, Issue 12 pp 3390—3399
Aging promotes neoplastic disease through effects on the tissue microenvironment
Figure 4. Panels (A) and (B) Expression of SA-β-gal in the liver of animals transplanted with pre-neoplastic hepatocytes in at young or old age and killed 3 months after Tx. The senescence marker was diffusely expressed in aged animals (panel B), while it was a rare finding in liver samples from young rats (panel A). Panel (C) Western Blot analysis of p21, p27 and p53 in liver samples from young and old recipients.