Research Paper Volume 8, Issue 12 pp 3486—3497
Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
Figure 4. Nematodes exposed to RNAi targeting human muscle-aggregate orthologs are resistant to amyloidopathy-induced paralysis. Muscle-specific induction of human Aβ1-42 expression during development causes paralysis to ensue over the ensuing 29 – 48 hr. Bars show the extent (mean ± SEM) to which treated worms were protected from amyloid-mediated paralysis, which left only 41% of control worms motile (N = 40 – 60 per group). Significant differences from control: ***P = 0.0005; ****P<0.0001.