Research Paper Volume 10, Issue 5 pp 902—929

Figure 1. Testosterone affects platelet aggregation induced by arachidonate or collagen in blood taken from men and from women. Data is presented as medians (thick horizontal lines) and interquartile ranges (IQR) (boxes, from lower quartile [25%] to upper quartile [75%]). Raw data is presented as black solid triangles or grey solid circles (outliers, by two-sided Tukey’s test: 1.5*[IQR]) for whole blood platelets stimulated with either arachidonate (0.5 mmol/l) (A, C) or collagen (1 µg/ml) (B, D) in men (A, B) and women (C, D). For experimental details, see Materials and methods. The significance of differences was estimated for Box-Cox-transformed data by the bootstrap-boosted (10000 iterations) ANOVA for repeated measures and the paired Student’s t-test with Bonferroni’s correction for post hoc multiple comparisons: P < 0.0005, µ₀ ≠ µ_0.1 = µ_0.5 = µ₁ = µ_2.5 = µ₅ = µ₁₀ for arachidonate-activated platelets in men; P < 0.001, µ₀ ≠ µ_0.1 = µ_0.5 = µ₁ = µ_2.5 = µ₅ = µ₁₀ for collagen-activated platelets in men; P < 0.001, µ₀ ≠ µ_0.1 = µ_0.5 = µ₁ = µ_2.5 = µ₅ = µ₁₀ for arachidonate-activated platelets in women; P < 0.05, µ₀ ≠ µ_0.1 = µ_0.5 = µ₁ = µ_2.5 = µ₅ = µ₁₀ for collagen-activated platelets in women.