Volume 10, Issue 5

Class IIa HDACs in myelination

Sergio Velasco-Aviles, Jose A. Gomez-Sanchez, Hugo Cabedo,

https://doi.org/10.18632/aging.101443 pp 853—854

PDF How to Cite Request Reprint

Cite this Article

How to cite

Velasco-Aviles S, Gomez-Sanchez JA, Cabedo H, . Class IIa HDACs in myelination. Aging (Albany NY). 2018 May 510:853-854. https://doi.org/10.18632/aging.101443

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Click to copy this citation from the text box above or download the citation:

Cell intrinsic Wnt/β-catenin signaling activation

Dominic B. Bernkopf, Jürgen Behrens,

https://doi.org/10.18632/aging.101455 pp 855—856

PDF How to Cite Request Reprint

TORC1, stress and the nucleolus

Emiliano Matos-Perdomo, Félix Machín,

https://doi.org/10.18632/aging.101456 pp 857—858

PDF How to Cite Request Reprint

Endothelial GABA signaling: a phoenix awakened

Yong Kee Choi, Anju Vasudevan,

https://doi.org/10.18632/aging.101457 pp 859—860

PDF How to Cite Request Reprint

Building lipids for myelin

Laura Montani, Ueli Suter,

https://doi.org/10.18632/aging.101458 pp 861—862

PDF How to Cite Request Reprint

It is necessary to establish an International Agency for Research on Aging

Vladimir N. Anisimov, Alexandre V. Sidorenko,

https://doi.org/10.18632/aging.101451 pp 863—867

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Anisimov VN, Sidorenko AV, . It is necessary to establish an International Agency for Research on Aging. Aging (Albany NY). 2018 May 1210:863-867. https://doi.org/10.18632/aging.101451

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Anisimov, Vladimir N. 
                AU  - Sidorenko, Alexandre V. 
                TI  - It is necessary to establish an International Agency for Research on Aging
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101451
                DO  - 10.18632/aging.101451
                SP  - 863
                EP  - 867
                PY  - 
                AB  - The global aging of human population is one of the main challenges and opportunities of the 21st century. Establishing an International Agency for Research on Aging as an entity affiliated to one of the intergovernmental institutions, such as the World Health Organization, can be crucial for promoting international collaboration in gerontology, in particular in a search of effective and safe geroprotectors for humans.
                ER  -

Click to copy this citation from the text box above or download the citation:

Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

Efstathios S. Gonos, Marianna Kapetanou, Jolanta Sereikaite, Grzegorz Bartosz, Katarzyna Naparło, Michalina Grzesik, Izabela Sadowska-Bartosz,

https://doi.org/10.18632/aging.101450 pp 868—901

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Gonos ES, Kapetanou M, Sereikaite J, Bartosz G, Naparło K, Grzesik M, Sadowska-Bartosz I, . Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging. Aging (Albany NY). 2018 May 1710:868-901. https://doi.org/10.18632/aging.101450

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Gonos, Efstathios S. 
                AU  - Kapetanou, Marianna 
                AU  - Sereikaite, Jolanta 
                AU  - Bartosz, Grzegorz 
                AU  - Naparło, Katarzyna 
                AU  - Grzesik, Michalina 
                AU  - Sadowska-Bartosz, Izabela 
                TI  - Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101450
                DO  - 10.18632/aging.101450
                SP  - 868
                EP  - 901
                PY  - 
                AB  - Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
                ER  -

Click to copy this citation from the text box above or download the citation:

Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women

Kamil Karolczak, Lucyna Konieczna, Tomasz Kostka, Piotr J. Witas, Bartlomiej Soltysik, Tomasz Baczek, Cezary Watala,

https://doi.org/10.18632/aging.101438 pp 902—929

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Karolczak K, Konieczna L, Kostka T, Witas PJ, Soltysik B, Baczek T, Watala C, . Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women. Aging (Albany NY). 2018 May 210:902-929. https://doi.org/10.18632/aging.101438

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Karolczak, Kamil 
                AU  - Konieczna, Lucyna 
                AU  - Kostka, Tomasz 
                AU  - Witas, Piotr J. 
                AU  - Soltysik, Bartlomiej 
                AU  - Baczek, Tomasz 
                AU  - Watala, Cezary 
                TI  - Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101438
                DO  - 10.18632/aging.101438
                SP  - 902
                EP  - 929
                PY  - 
                AB  - The cardiovascular effects of testosterone and dihydrotestosterone are generally attributed to their modulatory action on lipid and glucose metabolism. However, no ex vivo studies suggest that circulating androgen levels influence the activation and reactivity of blood platelets – one of the main components of the haemostasis system directly involved in atherosclerosis. The levels of testosterone, dihydrotestosterone and oestradiol in plasma from men and women aged from 60 to 65 years were measured by LC-MS; the aim was to identify any potential relationships between sex steroid levels and the markers of platelet activation (surface membrane expression of GPII/IIIa complex and P-selectin) and platelet reactivity in response to arachidonate, collagen or ADP, monitored with whole blood aggregometry and flow cytometry. The results of the ex vivo part of the study indicate that the concentrations of testosterone and its reduced form, dihydrotestosterone are significantly negatively associated with platelet activation and reactivity. These observations were confirmed in an in vitro model: testosterone and dihydrotestosterone significantly inhibited platelet aggregation triggered by arachidonate or collagen. Our findings indicate that testosterone and dihydrotestosterone are significant haemostatic steroids with inhibitory action on blood platelets in older people.
                ER  -

Click to copy this citation from the text box above or download the citation:

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

Benthe van der Lugt, Fenni Rusli, Carolien Lute, Andreas Lamprakis, Ethel Salazar, Mark V. Boekschoten, Guido J. Hooiveld, Michael Müller, Jacques Vervoort, Sander Kersten, Clara Belzer, Dieuwertje E.G. Kok, Wilma T. Steegenga,

https://doi.org/10.18632/aging.101439 pp 930—950

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

van der Lugt B, Rusli F, Lute C, Lamprakis A, Salazar E, Boekschoten MV, Hooiveld GJ, Müller M, Vervoort J, Kersten S, Belzer C, Kok DE, Steegenga WT, . Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice. Aging (Albany NY). 2018 May 1610:930-950. https://doi.org/10.18632/aging.101439

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - van der Lugt, Benthe 
                AU  - Rusli, Fenni 
                AU  - Lute, Carolien 
                AU  - Lamprakis, Andreas 
                AU  - Salazar, Ethel 
                AU  - Boekschoten, Mark V. 
                AU  - Hooiveld, Guido J. 
                AU  - Müller, Michael 
                AU  - Vervoort, Jacques 
                AU  - Kersten, Sander 
                AU  - Belzer, Clara 
                AU  - Kok, Dieuwertje E.G. 
                AU  - Steegenga, Wilma T. 
                TI  - Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101439
                DO  - 10.18632/aging.101439
                SP  - 930
                EP  - 950
                PY  - 
                ER  -

Provider: 
                TY  - JOUR
                AU  - van der Lugt, Benthe 
                AU  - Rusli, Fenni 
                AU  - Lute, Carolien 
                AU  - Lamprakis, Andreas 
                AU  - Salazar, Ethel 
                AU  - Boekschoten, Mark V. 
                AU  - Hooiveld, Guido J. 
                AU  - Müller, Michael 
                AU  - Vervoort, Jacques 
                AU  - Kersten, Sander 
                AU  - Belzer, Clara 
                AU  - Kok, Dieuwertje E.G. 
                AU  - Steegenga, Wilma T. 
                TI  - Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101439
                DO  - 10.18632/aging.101439
                SP  - 930
                EP  - 950
                PY  - 
                AB  - The aging process is associated with diminished colonic health. In this study, we applied an integrative approach to reveal potential interactions between determinants of colonic health in aging C57BL/6J mice. Analysis of gut microbiota composition revealed an enrichment of various potential pathobionts, including Desulfovibrio spp., and a decline of the health-promoting Akkermansia spp. and Lactobacillus spp. during aging. Intraluminal concentrations of various metabolites varied between ages and we found evidence for an increased gut permeability at higher age. Colonic gene expression analysis suggested that during the early phase of aging (between 6 and 12 months), expression of genes involved in epithelial-to-mesenchymal transition and (re)organization of the extracellular matrix were increased. Differential expression of these genes was strongly correlated with Bifidobacterium spp. During the later phase of aging (between 12 and 28 months), gene expression profiles pointed towards a diminished antimicrobial defense and were correlated with an uncultured Gastranaerophilales spp. This study demonstrates that aging is associated with pronounced changes in gut microbiota composition and colonic gene expression. Furthermore, the strong correlations between specific bacterial genera and host gene expression may imply that orchestrated interactions take place in the vicinity of the colonic wall and potentially mediate colonic health during aging.
                ER  -

Click to copy this citation from the text box above or download the citation:

Non-senescent Hydra tolerates severe disturbances in the nuclear lamina

Alexander Klimovich, Arvid Rehm, Jörg Wittlieb, Eva-Maria Herbst, Ricardo Benavente, Thomas C.G. Bosch,

https://doi.org/10.18632/aging.101440 pp 951—972

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018 May 1010:951-972. https://doi.org/10.18632/aging.101440

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
 TY - JOUR
 AU - Klimovich, Alexander 
 AU - Rehm, Arvid 
 AU - Wittlieb, Jörg 
 AU - Herbst, Eva-Maria 
 AU - Benavente, Ricardo 
 AU - Bosch, Thomas C.G. 
 TI - Non-senescent Hydra tolerates severe disturbances in the nuclear lamina
 JO - 
 JA - Aging (Albany NY)
 VL - 10
 IS - 5
 PB - 
 SN - 
 UR - https://doi.org/10.18632/aging.101440
 DO - 10.18632/aging.101440
 SP - 951
 EP - 972
 PY - 
 AB - The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra. We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for Hydra, the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of Hydra. A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans.
 ER -

Click to copy this citation from the text box above or download the citation:

Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma

Cheng-Cao Sun, Qun Zhou, Wei Hu, Shu-Jun Li, Feng Zhang, Zhen-Long Chen, Guang Li, Zhuo-Yue Bi, Yong-Yi Bi, Feng-Yun Gong, Tao Bo, Zhan-Peng Yuan, Wei-Dong Hu, Bo-Tao Zhan, Qian Zhang, Qi-Zhu Tang, De-Jia Li,

https://doi.org/10.18632/aging.101441 pp 973—987

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Sun C, Zhou Q, Hu W, Li S, Zhang F, Chen Z, Li G, Bi Z, Bi Y, Gong F, Bo T, Yuan Z, Hu W, et al, . Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma. Aging (Albany NY). 2018 May 1110:973-987. https://doi.org/10.18632/aging.101441

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Sun, Cheng-Cao 
                AU  - Zhou, Qun 
                AU  - Hu, Wei 
                AU  - Li, Shu-Jun 
                AU  - Zhang, Feng 
                AU  - Chen, Zhen-Long 
                AU  - Li, Guang 
                AU  - Bi, Zhuo-Yue 
                AU  - Bi, Yong-Yi 
                AU  - Gong, Feng-Yun 
                AU  - Bo, Tao 
                AU  - Yuan, Zhan-Peng 
                AU  - Hu, Wei-Dong 
                AU  - Zhan, Bo-Tao 
                AU  - Zhang, Qian 
                AU  - Tang, Qi-Zhu 
                AU  - Li, De-Jia 
                TI  - Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101441
                DO  - 10.18632/aging.101441
                SP  - 973
                EP  - 987
                PY  - 
                ER  -

Provider: 
                TY  - JOUR
                AU  - Sun, Cheng-Cao 
                AU  - Zhou, Qun 
                AU  - Hu, Wei 
                AU  - Li, Shu-Jun 
                AU  - Zhang, Feng 
                AU  - Chen, Zhen-Long 
                AU  - Li, Guang 
                AU  - Bi, Zhuo-Yue 
                AU  - Bi, Yong-Yi 
                AU  - Gong, Feng-Yun 
                AU  - Bo, Tao 
                AU  - Yuan, Zhan-Peng 
                AU  - Hu, Wei-Dong 
                AU  - Zhan, Bo-Tao 
                AU  - Zhang, Qian 
                AU  - Tang, Qi-Zhu 
                AU  - Li, De-Jia 
                TI  - Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101441
                DO  - 10.18632/aging.101441
                SP  - 973
                EP  - 987
                PY  - 
                AB  - E2F is a group of genes that encode a family of transcription factors (TFs) in higher eukaryotes and participate in cell cycle regulation and DNA synthesis in mammalian cells. Evidence from cell lines, mouse models, and human tissues indicates that TFs are implicated in lung cancer (LC) tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be elucidated. In the current study, we examined the transcriptional and survival data of E2Fs in patients with LC from ONCOMINE, GEPIA, Kaplan–Meier Plotter, and cBioPortal databases. We found that the expression levels of E2F1/2/3/5/6/7/8 were higher in lung adenocarcinoma and squamous cell lung carcinoma tissues than in lung tissues, whereas the expression level of E2F4 was lower in the former than in the latter. The expression levels of E2F2/4/5/7/8 were correlated with advanced tumor stage. Survival analysis using the Kaplan–Meier Plotter database revealed that the high transcription levels of E2F1/2/4/5/7/8 were associated with low relapse-free survival (RFS) in all of the patients with LC. Conversely, high E2F3/6 levels predicted high RFS in these patients. This study implied that E2F3/6/7 are potential targets of precision therapy for patients with LC and that E2F1/2/4/5/8 are new biomarkers for the prognosis of LC.
                ER  -

Click to copy this citation from the text box above or download the citation:

A novel functional polymorphism of GFAP decrease glioblastoma susceptibility through inhibiting the binding of miR-139

Jie Wang, Ming-Lei Wang, Chang-Hui Wang, Shu-Yan Sun, Han-Bing Zhang, Yang-Yang Jiang, Qi-Wu Xu, Ying Wang, Shi-Xin Gu,

https://doi.org/10.18632/aging.101442 pp 988—999

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Wang J, Wang M, Wang C, Sun S, Zhang H, Jiang Y, Xu Q, Wang Y, Gu S, . A novel functional polymorphism of GFAP decrease glioblastoma susceptibility through inhibiting the binding of miR-139. Aging (Albany NY). 2018 May 1010:988-999. https://doi.org/10.18632/aging.101442

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
 TY - JOUR
 AU - Wang, Jie 
 AU - Wang, Ming-Lei 
 AU - Wang, Chang-Hui 
 AU - Sun, Shu-Yan 
 AU - Zhang, Han-Bing 
 AU - Jiang, Yang-Yang 
 AU - Xu, Qi-Wu 
 AU - Wang, Ying 
 AU - Gu, Shi-Xin 
 TI - A novel functional polymorphism of GFAP decrease glioblastoma susceptibility through inhibiting the binding of miR-139
 JO - 
 JA - Aging (Albany NY)
 VL - 10
 IS - 5
 PB - 
 SN - 
 UR - https://doi.org/10.18632/aging.101442
 DO - 10.18632/aging.101442
 SP - 988
 EP - 999
 PY - 
 AB - Glioblastoma (GBM) is the most commonly diagnosed solid tumor outside the central nervous system. However, genetic factors underlying GBM remain largely unclear. Previous studies indicated that Glial fibrillary acidic protein (GFAP) might play an important role in the aggressiveness of GBM and also contributed to its poor overall survival. The present study aims to test (1) the associations between GFAP single nucleotide polymorphisms (SNPs) and GBM cells chemoresistance and metastasis, and (2) the molecular mechanism accounting for their effects. Four tagging SNPs of GFAP were initially genotyped in 667 subjects and the significant SNP was further analyzed via online bioinformatical tools. SNP rs11558961 was found to be significantly associated with GBM susceptibility. It was predicted to influence microRNA(miR)-139 binding to 3'UTR of GFAP gene. In functional experiments, we found that cells transfected with rs11558961 G-allele constructs had lower baseline luciferase activities and were more responsive to miR-139 changes, compared to C-allele constructs. Moreover, rs11558961 C&gt;G variant reduced the chemoresistance of GBM cells and migration capability. In conclusion, rs11558961 might influence the chemoresistance and progression of GBM cells via promoting the binding of miR-139, ultimately decrease the susceptibility of GBM. This investigation will shed light on the optimizing for clinical trial design and individualizing of therapeutic plans.
 ER -

Click to copy this citation from the text box above or download the citation:

Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development

Luca Falzone, Letizia Scola, Antonino Zanghì, Antonio Biondi, Antonio Di Cataldo, Massimo Libra, Saverio Candido,

https://doi.org/10.18632/aging.101444 pp 1000—1014

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Falzone L, Scola L, Zanghì A, Biondi A, Di Cataldo A, Libra M, Candido S, . Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development. Aging (Albany NY). 2018 May 1810:1000-1014. https://doi.org/10.18632/aging.101444

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Falzone, Luca 
                AU  - Scola, Letizia 
                AU  - Zanghì, Antonino 
                AU  - Biondi, Antonio 
                AU  - Di Cataldo, Antonio 
                AU  - Libra, Massimo 
                AU  - Candido, Saverio 
                TI  - Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101444
                DO  - 10.18632/aging.101444
                SP  - 1000
                EP  - 1014
                PY  - 
                AB  - Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently, no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore, there is a need to discover new molecules able to identify pre-cancerous lesions. Recently, microRNAs (miRNAs) have been associated with the onset of specific pathologies, thus the identification of miRNAs associated to colorectal cancer may be used to detect this pathology at early stages. On these bases, the expression levels of miRNAs were analyzed to compare the miRNAs expression levels of colorectal cancer samples and normal tissues in several miRNA datasets. This analysis revealed a group of 19 differentially expressed miRNAs. To establish the interaction between miRNAs and the most altered genes in CRC, the mirDIP gene target analysis was performed in such group of 19 differentially expressed miRNAs. To recognize miRNAs able to activate or inhibit genes and pathways involved in colorectal cancer development DIANA-mirPath prediction analysis was applied. Overall, these analyses showed that the up-regulated hsa-miR-183-5p and hsa-miR-21-5p, and the down-regulated hsa-miR-195-5p and hsa-miR-497-5p were directly related to colorectal cancer through the interaction with the Mismatch Repair pathway and Wnt, RAS, MAPK, PI3K, TGF-β and p53 signaling pathways involved in cancer development.
                ER  -

Click to copy this citation from the text box above or download the citation:

Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation

Chunxiao Li, Wenjing Gao, Ying Gao, Canqing Yu, Jun Lv, Ruoran Lv, Jiali Duan, Ying Sun, Xianghui Guo, Weihua Cao, Liming Li,

https://doi.org/10.18632/aging.101445 pp 1015—1026

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Li C, Gao W, Gao Y, Yu C, Lv J, Lv R, Duan J, Sun Y, Guo X, Cao W, Li L, . Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation. Aging (Albany NY). 2018 May 1210:1015-1026. https://doi.org/10.18632/aging.101445

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Li, Chunxiao 
                AU  - Gao, Wenjing 
                AU  - Gao, Ying 
                AU  - Yu, Canqing 
                AU  - Lv, Jun 
                AU  - Lv, Ruoran 
                AU  - Duan, Jiali 
                AU  - Sun, Ying 
                AU  - Guo, Xianghui 
                AU  - Cao, Weihua 
                AU  - Li, Liming 
                TI  - Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101445
                DO  - 10.18632/aging.101445
                SP  - 1015
                EP  - 1026
                PY  - 
                AB  - The DNA methylation age, a good reflection of human aging process, has been used to predict chronological age of adults and newborns. However, the prediction model for children and adolescents was absent. In this study, we aimed to generate a prediction model of chronological age for children and adolescents aged 6-17 years by using age-specific DNA methylation patterns from 180 Chinese twin individuals. We identified 6,350 age-related CpGs from the epigenome-wide association analysis (N=179). 116 known age-related sites in children were confirmed. 83 novel CpGs were selected as predictors from all age-related loci by elastic net regression and they could accurately predict the chronological age of the pediatric population, with a correlation of 0.99 and the error of 0.23 years in the training dataset (N=90). The predictive accuracy in the testing dataset (N=89) was high (correlation=0.93, error=0.62 years). Among the 83 predictors, 49 sites were novel probes not existing on the Illumina 450K BeadChip. The top two predictors of age were on the PRKCB and REG4 genes, which are associated with diabetes and cancer, respectively. Our results suggest that the chronological age can be accurately predicted among children and adolescents aged 6-17 years by 83 newly identified CpG sites.
                ER  -

Click to copy this citation from the text box above or download the citation:

Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Melissa M. Page, Eugene F. Schuster, Manikhandan Mudaliar, Pawel Herzyk, Dominic J. Withers, Colin Selman,

https://doi.org/10.18632/aging.101446 pp 1027—1052

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Page MM, Schuster EF, Mudaliar M, Herzyk P, Withers DJ, Selman C, . Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. Aging (Albany NY). 2018 May 2010:1027-1052. https://doi.org/10.18632/aging.101446

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Page, Melissa M. 
                AU  - Schuster, Eugene F. 
                AU  - Mudaliar, Manikhandan 
                AU  - Herzyk, Pawel 
                AU  - Withers, Dominic J. 
                AU  - Selman, Colin 
                TI  - Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101446
                DO  - 10.18632/aging.101446
                SP  - 1027
                EP  - 1052
                PY  - 
                AB  - Dietary restriction (DR) is the most widely studied non-genetic intervention capable of extending lifespan across multiple taxa. Modulation of genes, primarily within the insulin/insulin-like growth factor signalling (IIS) and the mechanistic target of rapamycin (mTOR) signalling pathways also act to extend lifespan in model organisms. For example, mice lacking insulin receptor substrate-1 (IRS1) are long-lived and protected against several age-associated pathologies. However, it remains unclear how these particular interventions act mechanistically to produce their beneficial effects. Here, we investigated transcriptional responses in wild-type and IRS1 null mice fed an ad libitum diet (WTAL and KOAL) or fed a 30% DR diet (WTDR or KODR). Using an RNAseq approach we noted a high correlation coefficient of differentially expressed genes existed within the same tissue across WTDR and KOAL mice and many metabolic features were shared between these mice. Overall, we report that significant overlap exists in the tissue-specific transcriptional response between long-lived DR mice and IRS1 null mice. However, there was evidence of disconnect between transcriptional signatures and certain phenotypic measures between KOAL and KODR, in that additive effects on body mass were observed but at the transcriptional level DR induced a unique set of genes in these already long-lived mice.
                ER  -

Click to copy this citation from the text box above or download the citation:

Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan

Tao Wang, Shao-Lei Geng, Yu-Min Guan, Wei-Hua Xu,

https://doi.org/10.18632/aging.101447 pp 1053—1072

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Wang T, Geng S, Guan Y, Xu W, . Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan. Aging (Albany NY). 2018 May 1610:1053-1072. https://doi.org/10.18632/aging.101447

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Wang, Tao 
                AU  - Geng, Shao-Lei 
                AU  - Guan, Yu-Min 
                AU  - Xu, Wei-Hua 
                TI  - Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101447
                DO  - 10.18632/aging.101447
                SP  - 1053
                EP  - 1072
                PY  - 
                AB  - Diapause in insects is akin to dauer in Caenorhabditis elegans and hibernation in vertebrates. Diapause causes a profound extension of lifespan by low metabolic activity. However, the detailed regulatory mechanisms for low metabolic activity remain unknown. Here, we showed that low pyruvate levels are present in the brains of diapause-destined pupae of the cotton bollworm Helicoverpa armigera, and three enzymes pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), and phosphoglycerate mutase (PGAM) are closely correlated with pyruvate homeostasis. Notably, Sirt2 can deacetylate the three enzymes to increase their activity in vitro. Thus, low Sirt2 expression in the brains of diapause individuals decreases PK and PEPCK protein levels as well as PGAM activity, resulting in low pyruvate levels and low tricarboxylic acid cycle activity and eventually inducing diapause initiation by low metabolic activity. These findings suggest that pyruvate is a checkpoint for development or lifespan extension, and Sirt2 is a negative regulator to extend lifespan in insects.
                ER  -

Click to copy this citation from the text box above or download the citation:

XPG rs17655 G>C polymorphism associated with cancer risk: evidence from 60 studies

Jie Zhao, Shanshan Chen, Haixia Zhou, Ting Zhang, Yang Liu, Jing He, Jinhong Zhu, Jichen Ruan,

https://doi.org/10.18632/aging.101448 pp 1073—1088

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Zhao J, Chen S, Zhou H, Zhang T, Liu Y, He J, Zhu J, Ruan J, . XPG rs17655 G>C polymorphism associated with cancer risk: evidence from 60 studies. Aging (Albany NY). 2018 May 2010:1073-1088. https://doi.org/10.18632/aging.101448

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
 TY - JOUR
 AU - Zhao, Jie 
 AU - Chen, Shanshan 
 AU - Zhou, Haixia 
 AU - Zhang, Ting 
 AU - Liu, Yang 
 AU - He, Jing 
 AU - Zhu, Jinhong 
 AU - Ruan, Jichen 
 TI - XPG rs17655 G>C polymorphism associated with cancer risk: evidence from 60 studies
 JO - 
 JA - Aging (Albany NY)
 VL - 10
 IS - 5
 PB - 
 SN - 
 UR - https://doi.org/10.18632/aging.101448
 DO - 10.18632/aging.101448
 SP - 1073
 EP - 1088
 PY - 
 AB - Xeroderma pigmentosum group G (XPG), a key component in nucleotide excision repair pathway, functions to cut DNA lesions during DNA repair. Genetic variations that alter DNA repair gene expression or function may decrease DNA repair ability and impair genome integrity, thereby predisposing to cancer. The association between XPG rs17655 G&gt;C polymorphism and cancer risk has been investigated extensively, but the results remain contradictory. To get a more accurate conclusion, we performed a comprehensive meta-analysis of 60 case-control studies, involving 27,098 cancer cases and 30,535 healthy controls. Crude odds ratios (ORs) and 95% confidence interval (CIs) were calculated to determine the association of interest. Pooled analysis indicated that the XPG rs17655 G&gt;C polymorphism increased the risk of overall cancer (CC vs. GG: OR=1.10, 95% CI=1.00-1.20; CG vs. GG: OR=1.06, 95% CI=1.02-1.11; CG+CC vs. GG: OR=1.07, 95% CI=1.02-1.12; C vs. G: OR=1.05, 95% CI=1.01-1.09). Stratification analysis by cancer type further showed that this polymorphism was associated with increased risk of gastric cancer and colorectal cancer. This meta-analysis indicated that the XPG gene rs17655 G&gt;C polymorphism was associated with increased overall cancer risk, especially the risk of gastric cancer and colorectal cancer. Further validation experiments are needed to strength our conclusion.
 ER -

Click to copy this citation from the text box above or download the citation:

Repeated superovulation increases the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging in mice

Jinjin Zhang, Zhiwen Lai, Liangyan Shi, Yong Tian, Aiyue Luo, Zheyuan Xu, Xiangyi Ma, Shixuan Wang,

https://doi.org/10.18632/aging.101449 pp 1089—1102

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Zhang J, Lai Z, Shi L, Tian Y, Luo A, Xu Z, Ma X, Wang S, . Repeated superovulation increases the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging in mice. Aging (Albany NY). 2018 May 2210:1089-1102. https://doi.org/10.18632/aging.101449

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Zhang, Jinjin 
                AU  - Lai, Zhiwen 
                AU  - Shi, Liangyan 
                AU  - Tian, Yong 
                AU  - Luo, Aiyue 
                AU  - Xu, Zheyuan 
                AU  - Ma, Xiangyi 
                AU  - Wang, Shixuan 
                TI  - Repeated superovulation increases the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging in mice
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101449
                DO  - 10.18632/aging.101449
                SP  - 1089
                EP  - 1102
                PY  - 
                AB  - Superovulation procedures and assisted reproductive technologies have been widely used to treat couples who have infertility problems. Although generally safe, the superovulation procedures are associated with a series of complications, such as ovarian hyper-stimulation syndrome, thromboembolism, and adnexal torsion. The role of long-term repeated superovulation in ovarian aging and especially in associated disorders such as osteoporosis and cardiovascular diseases is still unclear. In this study, we sought to determine if repeated superovulation by ten cycles of treatment with pregnant mare serum gonadotropin/human chorionic gonadotropin could affect ovarian reserve, ovarian function, bone density and heart function. Ovarian reserve and function were reflected by the size of the primordial follicle pool, anti-Mullerian hormone expressions, hormone levels and fertility status. Furthermore, we examined bone density and heart function by microCT and cardiovascular ultrasonography, respectively. After repeated superovulation, the size of the primordial follicle pool and the expression of anti-mullerian hormone decreased, along with the concentrations of estrogen and progesterone. Mice exposed to repeated superovulation showed an obvious decrease in fertility and fecundity. Furthermore, both bone density and heart ejection fraction significantly decreased. These results suggest that repeated superovulation may increase the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging.
                ER  -

Click to copy this citation from the text box above or download the citation:

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

Lucia Terlecki-Zaniewicz, Ingo Lämmermann, Julie Latreille, Madhusudhan Reddy Bobbili, Vera Pils, Markus Schosserer, Regina Weinmüllner, Hanna Dellago, Susanna Skalicky, Dietmar Pum, Juan Carlos Higareda Almaraz, Marcel Scheideler, Frédérique Morizot, Matthias Hackl, Florian Gruber, Johannes Grillari,

https://doi.org/10.18632/aging.101452 pp 1103—1132

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Terlecki-Zaniewicz L, Lämmermann I, Latreille J, Bobbili MR, Pils V, Schosserer M, Weinmüllner R, Dellago H, Skalicky S, Pum D, Almaraz JCH, Scheideler M, Morizot F, et al, . Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype. Aging (Albany NY). 2018 May 1910:1103-1132. https://doi.org/10.18632/aging.101452

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Terlecki-Zaniewicz, Lucia 
                AU  - Lämmermann, Ingo 
                AU  - Latreille, Julie 
                AU  - Bobbili, Madhusudhan Reddy 
                AU  - Pils, Vera 
                AU  - Schosserer, Markus 
                AU  - Weinmüllner, Regina 
                AU  - Dellago, Hanna 
                AU  - Skalicky, Susanna 
                AU  - Pum, Dietmar 
                AU  - Almaraz, Juan Carlos Higareda 
                AU  - Scheideler, Marcel 
                AU  - Morizot, Frédérique 
                AU  - Hackl, Matthias 
                AU  - Gruber, Florian 
                AU  - Grillari, Johannes 
                TI  - Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101452
                DO  - 10.18632/aging.101452
                SP  - 1103
                EP  - 1132
                PY  - 
                ER  -

Provider: 
                TY  - JOUR
                AU  - Terlecki-Zaniewicz, Lucia 
                AU  - Lämmermann, Ingo 
                AU  - Latreille, Julie 
                AU  - Bobbili, Madhusudhan Reddy 
                AU  - Pils, Vera 
                AU  - Schosserer, Markus 
                AU  - Weinmüllner, Regina 
                AU  - Dellago, Hanna 
                AU  - Skalicky, Susanna 
                AU  - Pum, Dietmar 
                AU  - Almaraz, Juan Carlos Higareda 
                AU  - Scheideler, Marcel 
                AU  - Morizot, Frédérique 
                AU  - Hackl, Matthias 
                AU  - Gruber, Florian 
                AU  - Grillari, Johannes 
                TI  - Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101452
                DO  - 10.18632/aging.101452
                SP  - 1103
                EP  - 1132
                PY  - 
                AB  - Loss of functionality during aging of cells and organisms is caused and accompanied by altered cell-to-cell communication and signalling. One factor thereby is the chronic accumulation of senescent cells and the concomitant senescence-associated secretory phenotype (SASP) that contributes to microenvironment remodelling and a pro-inflammatory status. While protein based SASP factors have been well characterized, little is known about small extracellular vesicles (sEVs) and their miRNA cargo. Therefore, we analysed secretion of sEVs from senescent human dermal fibroblasts and catalogued the therein contained miRNAs. We observed a four-fold increase of sEVs, with a concomitant increase of &gt;80% of all cargo miRNAs. The most abundantly secreted miRNAs were predicted to collectively target mRNAs of pro-apoptotic proteins, and indeed, senescent cell derived sEVs exerted anti-apoptotic activity. In addition, we identified senescence-specific differences in miRNA composition of sEVs, with an increase of miR-23a-5p and miR-137 and a decrease of miR-625-3p, miR-766-3p, miR-199b-5p, miR-381-3p, miR-17-3p. By correlating intracellular and sEV-miRNAs, we identified miRNAs selectively retained in senescent cells (miR-21-3p and miR-17-3p) or packaged specifically into senescent cell derived sEVs (miR-15b-5p and miR-30a-3p). Therefore, we suggest sEVs and their miRNA cargo to be novel, members of the SASP that are selectively secreted or retained in cellular senescence.
                ER  -

Click to copy this citation from the text box above or download the citation:

Chromatin changes trigger laminin genes dysregulation in aging kidneys

Oleg Denisenko, Daniel Mar, Matthew Trawczynski, Karol Bomsztyk,

https://doi.org/10.18632/aging.101453 pp 1133—1145

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Denisenko O, Mar D, Trawczynski M, Bomsztyk K, . Chromatin changes trigger laminin genes dysregulation in aging kidneys. Aging (Albany NY). 2018 May 2910:1133-1145. https://doi.org/10.18632/aging.101453

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Denisenko, Oleg 
                AU  - Mar, Daniel 
                AU  - Trawczynski, Matthew 
                AU  - Bomsztyk, Karol 
                TI  - Chromatin changes trigger laminin genes dysregulation in aging kidneys
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101453
                DO  - 10.18632/aging.101453
                SP  - 1133
                EP  - 1145
                PY  - 
                AB  - Dysregulation of gene expression is a hallmark of aging. We examined epigenetic mechanisms that mediate aberrant expression of laminin genes in aging rat kidneys. In old animals, no alterations were found in the levels of abundant laminin mRNAs, whereas Lama3, b3, and c2 transcripts were increased compared to young animals. Lamc2 showed the strongest changes at the mRNA and protein levels. Lamc2 upregulation was transcriptional, as indicated by the elevated RNA polymerase II density at the gene. Furthermore, aging is associated with the loss of H3K27m3 and 5mC silencing modifications at the Lamc2 gene. Western blot analysis revealed no changes in cellular levels of H3K27m3 and cognate enzyme Ezh2 in old kidneys. Thus, the decrease in H3K27m3 at Lamc2 resulted from the re-distribution of this mark among genomic sites. Studies in kidney cells in vitro showed that reducing H3K27m3 density with Ezh2 inhibitor had no effect on Lamc2 expression, suggesting that this modification plays little role in gene upregulation in aging kidney. In contrast, treatment with DNA methylation inhibitor 2'-deoxy-5-azacytidine was sufficient to upregulate Lamc2 gene. We suggest that the loss of 5mC at silenced laminin genes drives their de-repression during aging, contributing to the age-related decline in renal function.
                ER  -

Click to copy this citation from the text box above or download the citation:

Roles of three Es-Caspases during spermatogenesis and Cadmium-induced apoptosis in Eriocheir sinensis

Ya-Ru Xu, Wan-Xi Yang,

https://doi.org/10.18632/aging.101454 pp 1146—1165

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Xu Y, Yang W, . Roles of three Es-Caspases during spermatogenesis and Cadmium-induced apoptosis in Eriocheir sinensis. Aging (Albany NY). 2018 May 2410:1146-1165. https://doi.org/10.18632/aging.101454

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
 TY - JOUR
 AU - Xu, Ya-Ru 
 AU - Yang, Wan-Xi 
 TI - Roles of three Es-Caspases during spermatogenesis and Cadmium-induced apoptosis in Eriocheir sinensis
 JO - 
 JA - Aging (Albany NY)
 VL - 10
 IS - 5
 PB - 
 SN - 
 UR - https://doi.org/10.18632/aging.101454
 DO - 10.18632/aging.101454
 SP - 1146
 EP - 1165
 PY - 
 AB - Functions of Caspases remain obscure in Crustacea. We studied the existence and participations of apoptosis-related factors in Eriocheir sinensis testis. Three Es-Caspases (Es-Caspase 3/ 7/ 8) in E. sinensis were cloned and characterized. We observed that three es-caspases mRNA had specific expression patterns during spermiogenesis, with weak signal around the nucleus and invaginated acrosomal vesicle in early-stage spermatids, became stronger in middle-stage, finally focused on the acrosomal tube and nucleus in mature sperm. We then investigated the immunostaining intensity and positional alterations of Es-Caspase 3, Es-Caspase 8 and p53 during spermatogenesis, which were correlated with the differential tendencies of cells to undergo apoptosis and specific organelles shaping processes. After apoptotic induction by Cadmium, Es-Caspase 8 increased gradually, while Es-Caspase 3 increased firstly and then decreased, Es-p53 initially decreased and then increased. These results implies that Es-Caspase 3/ Es-Caspase 8/ p53 may play roles in Cadmium-induced apoptosis during spermatogenesis, and Caspase 8-Caspase 3-p53 pathway may interact with extrinsic or intrinsic pathways to regulate the destiny of sperm cells. Our study revealed the indispensable roles of Caspases during spermatogenesis and the possible molecular interactions in response to the Cadmium-induced apoptosis in E. sinensis, which filled the gap of apoptotic mechanisms of crustacean.
 ER -

Click to copy this citation from the text box above or download the citation:

Impact of long-term antihypertensive and antidiabetic medications on the prognosis of post-surgical colorectal cancer: the Fujian prospective investigation of cancer (FIESTA) study

Feng Peng, Dan Hu, Xiandong Lin, Binying Liang, Ying Chen, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu,

https://doi.org/10.18632/aging.101459 pp 1166—1181

View Abstract PDF Full-Text How to Cite Request Reprint

Cite this Article

How to cite

Peng F, Hu D, Lin X, Liang B, Chen Y, Zhang H, Xia Y, Lin J, Zheng X, Niu W, . Impact of long-term antihypertensive and antidiabetic medications on the prognosis of post-surgical colorectal cancer: the Fujian prospective investigation of cancer (FIESTA) study. Aging (Albany NY). 2018 May 2410:1166-1181. https://doi.org/10.18632/aging.101459

Copy or Download citation:

Select the format you require from the list below

Plain text
EndNote
Reference Manager
ProCite
BibteX

Provider: 
                TY  - JOUR
                AU  - Peng, Feng 
                AU  - Hu, Dan 
                AU  - Lin, Xiandong 
                AU  - Liang, Binying 
                AU  - Chen, Ying 
                AU  - Zhang, Hejun 
                AU  - Xia, Yan 
                AU  - Lin, Jinxiu 
                AU  - Zheng, Xiongwei 
                AU  - Niu, Wenquan 
                TI  - Impact of long-term antihypertensive and antidiabetic medications on the prognosis of post-surgical colorectal cancer: the Fujian prospective investigation of cancer (FIESTA) study
                JO  - 
                JA  - Aging (Albany NY)
                VL  - 10
                IS  - 5
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101459
                DO  - 10.18632/aging.101459
                SP  - 1166
                EP  - 1181
                PY  - 
                AB  - Hypertension and diabetes mellitus are common comorbidities of colorectal cancer. We designed a prospective cohort study aiming to investigate the impact of long-term antihypertensive and antidiabetic medications on colorectal cancer-specific survival and recurrence among 713 post-surgical patients. All participants received radical resection for colorectal cancer during 2000-08, and they were followed up until July 2017. Colorectal cancer patients without hypertension had better survival than those with hypertension (median survival time [MST]: 190.3 months versus 99.0 months, p &lt;0.001). The impact of antidiabetic medications on prolonging colorectal cancer survival was statistically significant, that is, patients receiving antidiabetic medications had longer survival time than untreated diabetic patients (MST: 135.8 months versus 80.2 months, p: 0.007), whereas the prognosis was greatly improved in colorectal cancer patients without diabetes mellitus (p &lt;0.001). Medical treatment for hypertension and diabetes mellitus was associated with 28% (hazard ratio [HR]: 0.72; 95% confidence interval [CI]: 0.47-1.10; p: 0.131) and 57% (HR: 0.43; 95% CI: 0.22-0.82; p: 0.010) reduced risk of dying from colorectal cancer relative to those without medications, respectively. Our data indicate that long-term antidiabetic medications can significantly prolong the survival and improve the prognosis of post-surgical colorectal cancer.
                ER  -

Click to copy this citation from the text box above or download the citation:

Volume 10, Issue 5

About the Cover

Editorials

Sergio Velasco-Aviles, Jose A. Gomez-Sanchez, Hugo Cabedo,

Cite this Article

How to cite

Copy or Download citation:

Dominic B. Bernkopf, Jürgen Behrens,

Cite this Article

How to cite

Copy or Download citation:

Emiliano Matos-Perdomo, Félix Machín,

Cite this Article

How to cite

Copy or Download citation:

Yong Kee Choi, Anju Vasudevan,

Cite this Article

How to cite

Copy or Download citation:

Laura Montani, Ueli Suter,

Cite this Article

How to cite

Copy or Download citation:

Research Perspective

Vladimir N. Anisimov, Alexandre V. Sidorenko,

Cite this Article

How to cite

Copy or Download citation:

Review

Efstathios S. Gonos, Marianna Kapetanou, Jolanta Sereikaite, Grzegorz Bartosz, Katarzyna Naparło, Michalina Grzesik, Izabela Sadowska-Bartosz,

Cite this Article

How to cite

Copy or Download citation:

Research Papers

Kamil Karolczak, Lucyna Konieczna, Tomasz Kostka, Piotr J. Witas, Bartlomiej Soltysik, Tomasz Baczek, Cezary Watala,

Cite this Article

How to cite

Copy or Download citation:

Benthe van der Lugt, Fenni Rusli, Carolien Lute, Andreas Lamprakis, Ethel Salazar, Mark V. Boekschoten, Guido J. Hooiveld, Michael Müller, Jacques Vervoort, Sander Kersten, Clara Belzer, Dieuwertje E.G. Kok, Wilma T. Steegenga,

Cite this Article

How to cite

Copy or Download citation:

Alexander Klimovich, Arvid Rehm, Jörg Wittlieb, Eva-Maria Herbst, Ricardo Benavente, Thomas C.G. Bosch,

Cite this Article

How to cite

Copy or Download citation:

Cheng-Cao Sun, Qun Zhou, Wei Hu, Shu-Jun Li, Feng Zhang, Zhen-Long Chen, Guang Li, Zhuo-Yue Bi, Yong-Yi Bi, Feng-Yun Gong, Tao Bo, Zhan-Peng Yuan, Wei-Dong Hu, Bo-Tao Zhan, Qian Zhang, Qi-Zhu Tang, De-Jia Li,

Cite this Article

How to cite

Copy or Download citation:

Jie Wang, Ming-Lei Wang, Chang-Hui Wang, Shu-Yan Sun, Han-Bing Zhang, Yang-Yang Jiang, Qi-Wu Xu, Ying Wang, Shi-Xin Gu,

Cite this Article

How to cite

Copy or Download citation:

Luca Falzone, Letizia Scola, Antonino Zanghì, Antonio Biondi, Antonio Di Cataldo, Massimo Libra, Saverio Candido,

Cite this Article

How to cite

Copy or Download citation:

Chunxiao Li, Wenjing Gao, Ying Gao, Canqing Yu, Jun Lv, Ruoran Lv, Jiali Duan, Ying Sun, Xianghui Guo, Weihua Cao, Liming Li,

Cite this Article

How to cite

Copy or Download citation:

Melissa M. Page, Eugene F. Schuster, Manikhandan Mudaliar, Pawel Herzyk, Dominic J. Withers, Colin Selman,

Cite this Article

How to cite

Copy or Download citation:

Tao Wang, Shao-Lei Geng, Yu-Min Guan, Wei-Hua Xu,

Cite this Article

How to cite

Copy or Download citation:

Jie Zhao, Shanshan Chen, Haixia Zhou, Ting Zhang, Yang Liu, Jing He, Jinhong Zhu, Jichen Ruan,

Cite this Article

How to cite

Copy or Download citation:

Jinjin Zhang, Zhiwen Lai, Liangyan Shi, Yong Tian, Aiyue Luo, Zheyuan Xu, Xiangyi Ma, Shixuan Wang,

Cite this Article

How to cite

Copy or Download citation:

Cite this Article

How to cite