Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Melissa M. Page; Eugene F. Schuster; Manikhandan Mudaliar; Pawel Herzyk; Dominic J. Withers; Colin Selman

doi:doi:10.18632/aging.101446

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Research Paper Volume 10, Issue 5 pp 1027—1052

Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Figure 1. Shared and distinct gene expression profile among four tissues in KO^AL mice. (a) Venn diagram of similar expressed genes across liver, skeletal muscle, brain and WAT tissue in KO^AL mice. Significantly up-regulated genes are shown in red and significantly down-regulated genes are shown in blue. Common genes that are significantly up- or down-regulated are found in overlapping ovals. The numbers in the bottom far right denotes the number of genes expressed but not significantly up-regulated (red) or down-regulated (blue). (b) Up-regulated gene ontology (GO) terms in liver, skeletal muscle, brain and WAT of KO^AL mice versus WT^AL mice. (c) Down-regulated GO terms in liver, skeletal muscle, brain and WAT of KO^AL mice.