Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Melissa M. Page; Eugene F. Schuster; Manikhandan Mudaliar; Pawel Herzyk; Dominic J. Withers; Colin Selman

doi:doi:10.18632/aging.101446

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Research Paper Volume 10, Issue 5 pp 1027—1052

Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Figure 8. Glucose and insulin metabolism in 15-month-old WT and KO mice. (a) Glucose tolerance curves (b) area under the curve (c) fed blood glucose (d) fasting circulating insulin levels. (e) Plasma resistin levels. WT^AL, n = 8; WT^DR, n = 6; KO^AL, n = 14; KO^DR, n = 10. Error bars represent mean ± SEM. * represents significant effect of treatment and ‡ represents significant effect of genotype. ‡ p < 0.05; **/‡‡ p < 0.01.