i.e. Italians) and we generated genome-wide data for 333 centenarians from the peninsula and 773 geographically-matched healthy individuals. Obtained results showed that: (i) centenarian genomes are enriched for an ancestral component likely shaped by pre-Neolithic migrations; (ii) centenarians born in Northern Italy unexpectedly clustered with controls from Central/Southern Italy suggesting that Neolithic and Bronze Age gene flow did not favor longevity in this population; (iii) local past adaptive events in response to pathogens and targeting arachidonic acid metabolism became favorable for longevity; (iv) lifelong changes in the frequency of several alleles revealed pleiotropy and trade-off mechanisms crucial for longevity. Therefore, we propose that demographic history and ancient/recent population dynamics need to be properly considered to identify genes involved in longevity, which can differ in different temporal/spatial settings." name="description"> Impact of demography and population dynamics on the genetic architecture of human longevity - Figure f1 | Aging
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Research Paper Volume 10, Issue 8 pp 1947—1963

Impact of demography and population dynamics on the genetic architecture of human longevity

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Figure 1. (A) Ancestry proportions at K = 5 estimated by ADMIXTURE analysis performed on Italian centenarians and controls, as well as on 50 Mediterranean and European populations. (B) First and second PCs calculated on the Italian general population (controls). Centenarians were projected as a supplementary group. Individuals from Northern Italy are indicated in blue, from Central Italy in green and from Southern Italy in red. Individuals from Sardinia are displayed in dark green.