i.e. Italians) and we generated genome-wide data for 333 centenarians from the peninsula and 773 geographically-matched healthy individuals. Obtained results showed that: (i) centenarian genomes are enriched for an ancestral component likely shaped by pre-Neolithic migrations; (ii) centenarians born in Northern Italy unexpectedly clustered with controls from Central/Southern Italy suggesting that Neolithic and Bronze Age gene flow did not favor longevity in this population; (iii) local past adaptive events in response to pathogens and targeting arachidonic acid metabolism became favorable for longevity; (iv) lifelong changes in the frequency of several alleles revealed pleiotropy and trade-off mechanisms crucial for longevity. Therefore, we propose that demographic history and ancient/recent population dynamics need to be properly considered to identify genes involved in longevity, which can differ in different temporal/spatial settings." name="description"> Impact of demography and population dynamics on the genetic architecture of human longevity - Figure f2 | Aging
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Research Paper Volume 10, Issue 8 pp 1947—1963

Impact of demography and population dynamics on the genetic architecture of human longevity

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Figure 2. Patterns of allele frequency in the Italian population. SNPs with significant differences in allele frequencies between Group1, Group2 and centenarians (Group 3) were divided into six different categories (Class A, B, C, D, E, F) according to their frequency trajectory over the three examined age intervals.