i.e. Italians) and we generated genome-wide data for 333 centenarians from the peninsula and 773 geographically-matched healthy individuals. Obtained results showed that: (i) centenarian genomes are enriched for an ancestral component likely shaped by pre-Neolithic migrations; (ii) centenarians born in Northern Italy unexpectedly clustered with controls from Central/Southern Italy suggesting that Neolithic and Bronze Age gene flow did not favor longevity in this population; (iii) local past adaptive events in response to pathogens and targeting arachidonic acid metabolism became favorable for longevity; (iv) lifelong changes in the frequency of several alleles revealed pleiotropy and trade-off mechanisms crucial for longevity. Therefore, we propose that demographic history and ancient/recent population dynamics need to be properly considered to identify genes involved in longevity, which can differ in different temporal/spatial settings." name="description"> Impact of demography and population dynamics on the genetic architecture of human longevity - Figure f3 | Aging
← Back
Research Paper Volume 10, Issue 8 pp 1947—1963

Impact of demography and population dynamics on the genetic architecture of human longevity

class="figure-viewer-img"

Figure 3. Overview of the diachronic approach used to combine information about processes occurred at different timescales (i.e. evolutionary and lifespan ones) in the study of the genetics of human longevity. (A) Northern European, N-E; Central/Eastern European, CE-E; Southern European, S-E; Middle Eastern, ME; Northern African, NA. (B) Each dot represents an individual in the general population - left - and in centenarians - right. The colour indicates the recruitment center and the position in the map indicates the genetic similarity).