Letter to the Editor Volume 10, Issue 8 pp 2209—2211

Figure 1. Possible mechanisms of spermidine-mediated rejuvenation. Spermidine may counteract the general clock of aging, by a global effect on cellular fitness (A), or may exert specific effects on multiple organ systems engaged in for example cardiovascular function, anticancer immune surveillance or neurodegeneration and thereby reducing the incidence of the major age-related diseases (B).