Research Paper Volume 10, Issue 12 pp 4120—4140

Figure 6. GSEA (Gene Set Enrichment Analysis) of the c-Myc signaling pathway based on the high and low expression of FoxM1 in ICC. The results indicated marked correlations of FoxM1 expression in ICC with the c-Myc signaling pathway (A and B). Subsequently, Western blotting verified that the overexpression of FoxM1 upregulates the activity of c-Myc signaling (C) and promotes MMP-9 and MMP-2 (D) protein expression in ICC. Statistics are shown with a bar graph. ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001.