<i>MicroRNA-335</i>/<i>ID4</i> dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia

Jing-dong Zhou; Xi-xi Li; Ting-juan Zhang; Zi-jun Xu; Zhi-hui Zhang; Yu Gu; Xiang-mei Wen; Wei Zhang; Run-bi Ji; Zhao-qun Deng; Jiang Lin; Jun Qian

doi:doi:10.18632/aging.101991

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Research Paper Volume 11, Issue 10 pp 3376—3391

MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia

Figure 2. Aberrant miR-335/ID4 expression predicted clinical outcome in AML. (A) The prognostic value of miR-335 expression for OS and LFS in non-M3-AML and CN-AML patients. (B) The prognostic value of ID4 expression for OS and LFS in non-M3-AML and CN-AML patients. (C) The prognostic value of ID4 expression for OS and LFS among CN-AML patients based on TCGA databases. (D) The prognostic value of ID4 expression for OS among CN-AML patients obtained by bioinformatics analysis. The effect of ID4 expression on prognosis was determined by the Genomicscape (http://genomicscape.com/microarray/survival.php). (E) The prognostic value of combined miR-335/ID4 expression for OS and LFS in non-M3-AML and CN-AML patients.