Research Paper Volume 11, Issue 14 pp 5008—5034

Figure 3. Rb1 prevented MPTP-induced altered gait dynamics. (A) shows the image extracted from a video recording of the underside of a walking mouse. (B–D) Effect of Rb1 on the stride time, stride length, and stride frequency in MPTP-treated mice. (E and F) Effect of Rb1 on the step sequence in MPTP-treated mice. Note that Rb1-prevented MPTP-induced disorder of step sequence as indicated by black dotted arrow in the figure. (G and H) Effect of Rb1 on the swing duration and ataxia coefficient in MPTP-treated mice. n = 12 per group. Results are expressed as the mean ± SEM. ^**P < 0.01 and ^*P < 0.05 vs. control group; ^##P < 0.01 vs. MPTP group. Statistical significance was determined by one-way ANOVA and the Bonferroni post-hoc test for pairwise comparisons.