Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 11, Issue 14

31 July, 2019
pp 4772—5286

About the Cover

The cover features Figure 18 "An “organelle biogenesis” approach to cancer therapy." from Peiris‐Pagès et al.

Explore This Issue

Editorials

MicroRNA Let-7adf in Tet regulation

Shuai Jiang,

https://doi.org/10.18632/aging.102101 pp 4772—4773

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Multidisciplinary teams for cardiogenic shock

Saarwaani Vallabhajosyula, Gregory W. Barsness, Saraschandra Vallabhajosyula,

https://doi.org/10.18632/aging.102104 pp 4774—4776

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Phenotypes of Klotho

Jyoti Misra Sen,

https://doi.org/10.18632/aging.102117 pp 4777—4778

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Righteousness (and lefteousness) of the old brain

Madalena Esteves, Nuno Sousa, Hugo Leite-Almeida,

https://doi.org/10.18632/aging.102127 pp 4779—4780

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Aging heart and infection

Colwyn Headley, Joanne Turner, Murugesan VS Rajaram,

https://doi.org/10.18632/aging.102128 pp 4781—4782

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Priority Research Paper

The metabolomic signature of extreme longevity: naked mole rats versus mice

Mélanie Viltard, Sylvère Durand, Maria Pérez-Lanzón, Fanny Aprahamian, Deborah Lefevre, Christine Leroy, Frank Madeo, Guido Kroemer, Gérard Friedlander,

https://doi.org/10.18632/aging.102116 pp 4783—4800

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Research Papers

Mitochondrial and ribosomal biogenesis are new hallmarks of stemness, oncometabolism and biomass accumulation in cancer: Mito‐stemness and ribo‐stemness features

Maria Peiris‐Pagès, Béla Ozsvári, Federica Sotgia, Michael P. Lisanti,

https://doi.org/10.18632/aging.102054 pp 4801—4835

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Effects of transcutaneous vagus nerve stimulation in individuals aged 55 years or above: potential benefits of daily stimulation

Beatrice Bretherton, Lucy Atkinson, Aaron Murray, Jennifer Clancy, Susan Deuchars, Jim Deuchars,

https://doi.org/10.18632/aging.102074 pp 4836—4857

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CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling

Chunyong Han, Xuebiao Li, Qian Fan, Guangshu Liu, Jian Yin,

https://doi.org/10.18632/aging.102080 pp 4858—4875

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LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis

Zhaozhi Wang, Jianjun Jin,

https://doi.org/10.18632/aging.102081 pp 4876—4889

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GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer

Ting Guo, Bin Li, Chao Gu, Xiuying Chen, Mengxin Han, Xiaocheng Liu, Congjian Xu,

https://doi.org/10.18632/aging.102082 pp 4890—4899

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Osteoprotegerin as a biomarker of geriatric frailty syndrome

Alessia Valentini, Maria Assunta Cianfarani, Umberto Tarantino, Nicola Di Daniele, Aldo Bertoli,

https://doi.org/10.18632/aging.102083 pp 4900—4909

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Blood autophagy defect causes accelerated non-hematopoietic organ aging

Yixuan Fang, Lingjiang Zhu, Ni An, Gaoyue Jiang, Jiawei Qian, Ruijin Zhao, Na Yuan, Suping Zhang, Jianrong Wang,

https://doi.org/10.18632/aging.102086 pp 4910—4922

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The positive impacts of early-life education on cognition, leisure activity, and brain structure in healthy aging

Yaojing Chen, Chenlong Lv, Xin Li, Junying Zhang, Kewei Chen, Zhongwan Liu, He Li, Jialing Fan, Ting Qin, Liang Luo, Zhanjun Zhang,

https://doi.org/10.18632/aging.102088 pp 4923—4942

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D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy

Lexiang Yu, Yao Chen, Yong Xu, Tao He, Yan Wei, Rongqiao He,

https://doi.org/10.18632/aging.102089 pp 4943—4969

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Optimism is not associated with two indicators of DNA methylation aging

Eric S. Kim, Kelvin Fong, Lewina Lee, Avron Spiro, Joel Schwartz, Eric Whitsel, Steve Horvath, Cuicui Wang, Lifang Hou, Andrea A. Baccarelli, Yun Li, James Stewart, JoAnn E. Manson, Francine Grodstein, Dawn L. DeMeo, Laura D. Kubzansky,

https://doi.org/10.18632/aging.102090 pp 4970—4989

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Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2

Bo Jia, Tao Xie, Xiaoling Qiu, Xiang Sun, Jun Chen, Zhijie Huang, Xianghuai Zheng, Zhiping Wang, Jianjiang Zhao,

https://doi.org/10.18632/aging.102094 pp 4990—5007

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Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice

Yan Liu, Xiaodan Zong, Jie Huang, Yanfei Guan, Yuanquan Li, Ting Du, Keyin Liu, Xinpan Kang, Chunyan Dou, Xiangdong Sun, Renhua Wu, Lei Wen, Yunlong Zhang,

https://doi.org/10.18632/aging.102095 pp 5008—5034

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Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer

Yilong Li, Rui Kong, Hongze Chen, Zhongjie Zhao, Le Li, Jiating Li, Jisheng Hu, Guangquan Zhang, Shangha Pan, Yongwei Wang, Gang Wang, Hua Chen, Bei Sun,

https://doi.org/10.18632/aging.102096 pp 5035—5057

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miR-548d-3p inhibits osteosarcoma by downregulating KRAS

Jianhua Chen, Chongnan Yan, Honghao Yu, Shihan Zhen, Quan Yuan,

https://doi.org/10.18632/aging.102097 pp 5058—5069

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Shortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy men

Naiara Cinegaglia, Luiza Antoniazzi, Daniela Rosa, Debora Miranda, Julio Acosta-Navarro, Luiz Bortolotto, Valeria Hong, Valeria Sandrim,

https://doi.org/10.18632/aging.102098 pp 5070—5080

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Better prognostic determination and feature characterization of cutaneous melanoma through integrative genomic analysis

Xia Li, Yunpeng Cai,

https://doi.org/10.18632/aging.102099 pp 5081—5107

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Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21

Hongzhi Wan, Ying Yang, Miao Li, Xin Liu, Yeying Sun, Kexin Wang, Chunxiang Zhang, Qingyin Zheng, Chaoyun Wang,

https://doi.org/10.18632/aging.102106 pp 5108—5123

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Novel serum metabolites associate with cognition phenotypes among Bogalusa Heart Study participants

Mengyao Shi, Lydia A. Bazzano, Jiang He, Xiaoying Gu, Changwei Li, Shengxu Li, Kristine Yaffe, Jason M. Kinchen, Patrick Stuchlik, Xuenan Mi, Jovia L. Nierenberg, Alexander C. Razavi, Tanika N. Kelly,

https://doi.org/10.18632/aging.102107 pp 5124—5139

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Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

Ashok Kumar, Jeffrey S. Thinschmidt, Thomas C. Foster,

https://doi.org/10.18632/aging.102108 pp 5140—5157

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The diagnostic and prognostic role of RhoA in hepatocellular carcinoma

Yi Bai, Fucun Xie, Fei Miao, Junyu Long, Shan Huang, Hanchun Huang, Jianzhen Lin, Dongxu Wang, Xu Yang, Jin Bian, Jinzhu Mao, Xi Wang, Yilei Mao, Xinting Sang, Haitao Zhao,

https://doi.org/10.18632/aging.102110 pp 5158—5172

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Genetic polymorphisms and transcription profiles associated with intracranial aneurysm: a key role for NOTCH3

Mengqi Li, Xinlong Dong, Shi Chen, Weihan Wang, Chao Yang, Bochuan Li, Degang Liang, Weidong Yang, Xiaozhi Liu, Xinyu Yang,

https://doi.org/10.18632/aging.102111 pp 5173—5191

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Down-regulation of lncRNA MALAT1 alleviates vascular lesion and vascular remodeling of rats with hypertension

Yu-Zeng Xue, Zhi-Juan Li, Wei-Tao Liu, Jin-Jiao Shan, Lei Wang, Qian Su,

https://doi.org/10.18632/aging.102113 pp 5192—5205

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Sex-specific components of frailty in C57BL/6 mice

Cory W. Baumann, Dongmin Kwak, LaDora V. Thompson,

https://doi.org/10.18632/aging.102114 pp 5206—5214

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Profiling of mRNA of interstitial fibrosis and tubular atrophy with subclinical inflammation in recipients after kidney transplantation

Qiang Fu, Minxue Liao, Cheng Feng, Jichao Tang, Rui Liao, Liang Wei, Hongji Yang, James F. Markmann, Kai Chen, Shaoping Deng,

https://doi.org/10.18632/aging.102115 pp 5215—5231

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Aberrant DNA methylation of synaptophysin is involved in adrenal cortisol-producing adenoma

Jia-Yu Zhong, Rong-Rong Cui, Xiao Lin, Feng Xu, Ting Zhu, Fuxingzi Li, Feng Wu, En Zhou, Lu Yi, Ling-Qing Yuan,

https://doi.org/10.18632/aging.102119 pp 5232—5245

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Immune system development and age-dependent maintenance in Klotho-hypomorphic mice

Wandi Sandra Zhu, Lynette Naler, Robert W. Maul, Michelle A. Sallin, Jyoti Misra Sen,

https://doi.org/10.18632/aging.102121 pp 5246—5257

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Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency

Veronika Bezold, Philip Rosenstock, Jonas Scheffler, Henriette Geyer, Rüdiger Horstkorte, Kaya Bork,

https://doi.org/10.18632/aging.102123 pp 5258—5275

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Aging induces a step-like change in the motor ability structure of athletes

Siddhartha Bikram Panday, Prabhat Pathak, Jeongin Moon, Jooeun Ahn,

https://doi.org/10.18632/aging.102126 pp 5276—5286

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