Research Paper Volume 11, Issue 14 pp 5008—5034

Figure 8. Rb1 attenuates memory impairments in the MPTP mouse model of PD. (A) Representative path tracings in the open field test. (B–E) Total travelled distance, movement speed, number of entries to the center, and the time spent in the center of the open-field after Rb1 administration in MPTP-treated mice. (F) T-maze results after Rb1 administration in MPTP-treated mice are presented as alternation triplets (consecutive triplets of different arm-choices). (G) Design of the novel-object recognition (NOR) task. In the training phase, the mouse is exposed to two objects “A” and “B”. In the testing phase 1 h later, the mouse is exposed to the same object “A” and a novel object “C”. (H) Percent time spent with object A or B in the training phase of the NOR test. (I) Results from the testing phase of the NOR test show percent time spent with the novel object (exploratory preference). n = 8 in control group, n = 9 in MPTP group, n = 10 in MPTP+Rb1 group and n = 8 in Rb1 group. Results are expressed as the mean ± SEM. ^**P < 0.01 and ^*P < 0.05 vs. control group; ^##P < 0.01 and ^#P < 0.05 vs. MPTP group. Statistical significance was determined by one-way ANOVA and the Bonferroni post-hoc test for pairwise comparisons.