Research Paper Volume 11, Issue 16 pp 6199—6216

Figure 4. The amplitude and frequency of STOCs are lower in HFD DSM cells than in ND DSM cells. Representative STOC recordings in ND and HFD DSM cells at −40 mV. (A) and 0 mV (B). (C) The differences in the mean STOC amplitudes of ND and HFD DSM cells at −40 mV and 0 mV. (D) Comparison of the average STOC frequency in ND and HFD DSM cells at −40 mV and 0 mV. Data are expressed as the mean ± SEM; n = 14, N = 7 in the ND group, n = 14, N = 6 in the HFD group; * P < 0.05 for ND vs. HFD. ND: normal diet; HFD: high-fat diet; STOC: spontaneous transient outward current; NS: not significant.