Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 11, Issue 16

31 August, 2019
pp 5864—6613

About the Cover

The cover feature Figure 2 "Regional Manhattan plots and inter-CpG correlations for the top four genes identified in the global meta-analysis" from Lee et al. Aging devoted the Cover to a special roundtable discussion involving Dr. Yunsung Lee, Dr. Anil P.S. Ori, Dr. Ake T. Lu, and Dr. Steve Horvath talking about the connections between two papers published in current issue “Epigenome-wide association study of leukocyte telomere length” and “DNA methylation-based estimator of telomere length"

Explore This Issue

Editorials

Longevity or hypoxia: who’s driving?

Matthew E. Pamenter, Daniel Munro,

https://doi.org/10.18632/aging.102174 pp 5864—5865

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The anti-inflammatory effects of SGLT inhibitors

Álvaro García-Ropero, Carlos G Santos-Gallego, Juan J. Badimon,

https://doi.org/10.18632/aging.102175 pp 5866—5867

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Rapamycin protects aging muscle

Huibin Tang, Joseph B. Shrager, Daniel Goldman,

https://doi.org/10.18632/aging.102176 pp 5868—5870

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Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease

Nikhil Panicker, Arthi Kanthasamy, Anumantha G. Kanthasamy,

https://doi.org/10.18632/aging.102210 pp 5871—5873

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Sources of ILC2s: diverse locations and precursors

Xiao-Hong Sun,

https://doi.org/10.18632/aging.102222 pp 5874—5875

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Research Papers

Epigenome-wide association study of leukocyte telomere length

Yunsung Lee, Dianjianyi Sun, Anil P.S. Ori, Ake T. Lu, Anne Seeboth, Sarah E. Harris, Ian J. Deary, Riccardo E. Marioni, Mette Soerensen, Jonas Mengel-From, Jacob Hjelmborg, Kaare Christensen, James G. Wilson, Daniel Levy, Alex P. Reiner, Wei Chen, Shengxu Li, Jennifer R. Harris, Per Magnus, Abraham Aviv, Astanand Jugessur, Steve Horvath,

https://doi.org/10.18632/aging.102230 pp 5876—5894

View Abstract PDF Full-Text How to Cite Special Collection on Steve Horvath's Publications in Aging (Albany NY)

DNA methylation-based estimator of telomere length

Ake T. Lu, Anne Seeboth, Pei-Chien Tsai, Dianjianyi Sun, Austin Quach, Alex P. Reiner, Charles Kooperberg, Luigi Ferrucci, Lifang Hou, Andrea A. Baccarelli, Yun Li, Sarah E. Harris, Janie Corley, Adele Taylor, Ian J. Deary, James D. Stewart, Eric A. Whitsel, Themistocles L. Assimes, Wei Chen, Shengxu Li, Massimo Mangino, Jordana T. Bell, James G. Wilson, Abraham Aviv, Riccardo E. Marioni, Kenneth Raj, Steve Horvath,

https://doi.org/10.18632/aging.102173 pp 5895—5923

View Abstract PDF Full-Text How to Cite Special Collection on Steve Horvath's Publications in Aging (Albany NY)

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus

Camilo Toledo, Claudia Lucero, David C. Andrade, Hugo S. Díaz, Karla G. Schwarz, Katherin V. Pereyra, Alexis Arce-Álvarez, Nicolás A. López, Milka Martinez, Nibaldo C. Inestrosa, Rodrigo Del Rio,

https://doi.org/10.18632/aging.102150 pp 5924—5942

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Discovering markers of healthy aging: a prospective study in a Danish male birth cohort

Kiyana Zarnani, Thomas E. Nichols, Fidel Alfaro-Almagro, Birgitte Fagerlund, Martin Lauritzen, Egill Rostrup, Stephen M. Smith,

https://doi.org/10.18632/aging.102151 pp 5943—5974

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LINC00511 promotes the malignant phenotype of clear cell renal cell carcinoma by sponging microRNA-625 and thereby increasing cyclin D1 expression

Huanghao Deng, Changkun Huang, Yinhuai Wang, Hongyi Jiang, Shuang Peng, Xiaokun Zhao,

https://doi.org/10.18632/aging.102156 pp 5975—5991

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LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts

Mengna Li, Li Li, Xiaofeng Zhang, Huijuan Zhao, Min Wei, Wanying Zhai, Baoxi Wang, Yan Yan,

https://doi.org/10.18632/aging.102159 pp 5992—6013

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MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin

Xin Liu, Liangliang Liu, Hongbo Zhang, Yan Shao, Ziyu Chen, Xiaofeng Feng, Hang Fang, Chang Zhao, Jianying Pan, Haiyan Zhang, Chun Zeng, Daozhang Cai,

https://doi.org/10.18632/aging.102160 pp 6014—6028

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Identification of 9 key genes and small molecule drugs in clear cell renal cell carcinoma

Yongwen Luo, Dexin Shen, Liang Chen, Gang Wang, Xuefeng Liu, Kaiyu Qian, Yu Xiao, Xinghuan Wang, Lingao Ju,

https://doi.org/10.18632/aging.102161 pp 6029—6052

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LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma

Wei-Lin Chen, Hong-Jin Chen, Guo-Qiang Hou, Xiao-Hua Zhang, Jian-Wei Ge,

https://doi.org/10.18632/aging.102162 pp 6053—6068

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FAM83A signaling induces epithelial-mesenchymal transition by the PI3K/AKT/Snail pathway in NSCLC

Fengrui Zhou, Jianxiong Geng, Shanqi Xu, Qingwei Meng, Kexin Chen, Fang Liu, Fang Yang, Bo Pan, Yan Yu,

https://doi.org/10.18632/aging.102163 pp 6069—6088

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Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancer

Huimin Liu, Xiaoyu Gu, Guihua Wang, Ying Huang, Shaoqing Ju, Jianfei Huang, Xudong Wang,

https://doi.org/10.18632/aging.102168 pp 6089—6108

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Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease

Cuihua Zou, Jie Wang, Xiaohua Huang, Chongdong Jian, Donghua Zou, Xuebin Li,

https://doi.org/10.18632/aging.102169 pp 6109—6119

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MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice

Qingbin Wu, Xiaochen Yuan, Jing Bai, Ruiqin Han, Zhigang Li, Honggang Zhang, Ruijuan Xiu,

https://doi.org/10.18632/aging.102171 pp 6120—6133

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Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity

Olga I. Kechko, Irina Yu. Petrushanko, Christopher S. Brower, Alexei A. Adzhubei, Alexey A. Moskalev, Konstantin I. Piatkov, Vladimir A. Mitkevich, Alexander A. Makarov,

https://doi.org/10.18632/aging.102177 pp 6134—6152

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Prognostic value of genome-wide DNA methylation patterns in noncoding miRNAs and lncRNAs in uveal melanomas

Zheng Zheng, Dan Xu, Keqing Shi, Minfeng Chen, Fan Lu,

https://doi.org/10.18632/aging.102178 pp 6153—6174

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Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

Daniel Moreno-Blas, Elisa Gorostieta-Salas, Alexander Pommer-Alba, Gabriel Muciño-Hernández, Cristian Gerónimo-Olvera, Luis Angel Maciel-Barón, Mina Konigsberg, Lourdes Massieu, Susana Castro-Obregón,

https://doi.org/10.18632/aging.102181 pp 6175—6198

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Attenuated BK channel function promotes overactive bladder in a rat model of obesity

Ning Li, Honglin Ding, Peng Zhang, Zizheng Li, Yili Liu, Ping Wang,

https://doi.org/10.18632/aging.102182 pp 6199—6216

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Risk estimation before progression to mild cognitive impairment and Alzheimer’s disease: an AD resemblance atrophy index

Lei Zhao, Yishan Luo, Darson Lew, Wenyan Liu, Lisa Au, Vincent Mok, Lin Shi, for the Alzheimer Disease Neuroimaging Initiative,

https://doi.org/10.18632/aging.102184 pp 6217—6236

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Prognostic value of long non-coding RNA signatures in bladder cancer

Anbang He, Shiming He, Ding Peng, Yonghao Zhan, Yifan Li, Zhicong Chen, Yanqing Gong, Xuesong Li, Liqun Zhou,

https://doi.org/10.18632/aging.102185 pp 6237—6251

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Prognostic value of preoperative hematological markers combined with molecular pathology in patients with diffuse gliomas

Zhen-Yu Zhang, Yun-Bo Zhan, Feng-Jiang Zhang, Bin Yu, Yu-Chen Ji, Jin-Qiao Zhou, Ya-Hui Bai, Yan-Min Wang, Li Wang, Yan Jing, Wen-Chao Duan, Chen Sun, Tao Sun, Hai-Biao Zhao, Ke Li, Wen-Qing Wang, Ruo-Yan Li, Hong-Wei Sun, Guang Zhai, Shu-Kai Wang, Xin-Ting Wei, Bo Yang, Dong-Ming Yan, Xian-Zhi Liu, Wei-Wei Wang,

https://doi.org/10.18632/aging.102186 pp 6252—6272

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Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma

Chuan-Yuan Wei, Meng-Xuan Zhu, Peng-Fei Zhang, Xuan Yang, Lu Wang, Jiang-Hui Ying, Wen-Jie Luan, Cheng Chen, Jia-Qi Liu, Ming Zhu, Yan-wen Yang, Zi-Hao Feng, Fa-Zhi Qi, Jian-Ying Gu,

https://doi.org/10.18632/aging.102187 pp 6273—6285

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Efficacy and safety of neoadjuvant chemotherapy regimens for triple-negative breast cancer: a network meta-analysis

Yunhai Li, Dejuan Yang, Ping Chen, Xuedong Yin, Jiazheng Sun, Hongzhong Li, Guosheng Ren,

https://doi.org/10.18632/aging.102188 pp 6286—6311

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Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma

Xuesi Dong, Ruyang Zhang, Jieyu He, Linjing Lai, Raphael N. Alolga, Sipeng Shen, Ying Zhu, Dongfang You, Lijuan Lin, Chao Chen, Yang Zhao, Weiwei Duan, Li Su, Andrea Shafer, Moran Salama, Thomas Fleischer, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Rui Wang, Johan Staaf, Åslaug Helland, Manel Esteller, Yongyue Wei, Feng Chen, David C. Christiani,

https://doi.org/10.18632/aging.102189 pp 6312—6335

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Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

Alberto Granzotto, Manuela Bomba, Vanessa Castelli, Riccardo Navarra, Noemi Massetti, Marco d’Aurora, Marco Onofrj, Ilaria Cicalini, Piero del Boccio, Valentina Gatta, Annamaria Cimini, Daniele Piomelli, Stefano L. Sensi,

https://doi.org/10.18632/aging.102191 pp 6336—6357

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Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation

Ran-Ran Qin, Hui Zhu, Feng Wang, Ming Song, Pei-Lin Lin, Yan-Qiu Xing, Wei Zhang, Ming Zhong, Zhi-Hao Wang,

https://doi.org/10.18632/aging.102192 pp 6358—6370

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MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

Chen Cai, Shaoxiong Min, Bo Yan, Wen Liu, Xiao Yang, Liuxun Li, Ting Wang, Anmin Jin,

https://doi.org/10.18632/aging.102194 pp 6371—6384

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Low triiodothyronine syndrome is associated with hemorrhagic transformation in patients with acute ischaemic stroke

Gui-Qian Huang, Ya-Ying Zeng, Qian-Qian Cheng, Hao-Ran Cheng, Yi-Ting Ruan, Cheng-Xiang Yuan, Yun-Bin Chen, Wei-Lei He, Hui-Jun Chen, Jin-Cai He,

https://doi.org/10.18632/aging.102195 pp 6385—6397

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Comprehensive transcriptomic analysis indicates brain regional specific alterations in type 2 diabetes

Zhe Zhou, Yizhang Zhu, Yang Liu, Yuxin Yin,

https://doi.org/10.18632/aging.102196 pp 6398—6421

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A disparate role of RP11-424C20.2/UHRF1 axis through control of tumor immune escape in liver hepatocellular carcinoma and thymoma

Jue Yang, Yongqiang Zhang, Hui Song,

https://doi.org/10.18632/aging.102197 pp 6422—6439

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FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

Xiaoe Lang, Wenzhong Zhang, Xinxin Song, Guangya Zhang, Xiangdong Du, Yongjie Zhou, Zezhi Li, Xiang Yang Zhang,

https://doi.org/10.18632/aging.102198 pp 6440—6448

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Quantitative analysis of the human ovarian carcinoma mitochondrial phosphoproteome

Na Li, Shehua Qian, Biao Li, Xianquan Zhan,

https://doi.org/10.18632/aging.102199 pp 6449—6468

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Identification and validation of four hub genes involved in the plaque deterioration of atherosclerosis

Peipei Chen, Yuexin Chen, Wei Wu, Lianfeng Chen, Xufei Yang, Shuyang Zhang,

https://doi.org/10.18632/aging.102200 pp 6469—6489

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Down-regulation of Cav1.3 in auditory pathway promotes age-related hearing loss by enhancing calcium-mediated oxidative stress in male mice

Fan Qi, Rongsheng Zhang, Jin Chen, Fei Zhao, Yanbo Sun, Zhihui Du, Dan Bing, Pengjun Li, Shengli Shao, Hongmei Zhu, Hanqi Chu,

https://doi.org/10.18632/aging.102203 pp 6490—6502

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Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma

Wen-Hao Xu, Yue Xu, Jun Wang, Xi Tian, Junlong Wu, Fang-Ning Wan, Hong-Kai Wang, Yuan-Yuan Qu, Hai-Liang Zhang, Ding-Wei Ye,

https://doi.org/10.18632/aging.102206 pp 6503—6521

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Strict target blood pressure management for reducing the stroke risk according to 2017 ACC/AHA blood pressure guideline

Peng Zhao, Jie Liu, Conglin Wang, Wei Zhao, Yanqiu Zhang, Hongfei Gu, Jun Tu, Jinghua Wang, Xianjia Ning,

https://doi.org/10.18632/aging.102207 pp 6522—6534

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Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span

Silvia Maglioni, Danielle F. Mello, Alfonso Schiavi, Joel N. Meyer, Natascia Ventura,

https://doi.org/10.18632/aging.102208 pp 6535—6554

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LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice

Marco Malavolta, Serena Dato, Francesco Villa, Francesco De Rango, Francesca Iannone, Anna Ferrario, Anna Maciag, Elena Ciaglia, Antonio D'amato, Albino Carrizzo, Andrea Basso, Fiorenza Orlando, Mauro Provinciali, Paolo Madeddu, Giuseppe Passarino, Carmine Vecchione, Giuseppina Rose, Annibale A Puca,

https://doi.org/10.18632/aging.102209 pp 6555—6568

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Genetic variants of ADAMTS7 confer risk for ischaemic stroke in the Chinese population

Linfa Chen, Weidong Hu, Shengnan Li, Shaoyu Yao, Mengxu Wang, Xinglan Chen, Shaofeng Chen, Fu Deng, Peiyi Zhu, Keshen Li, Wangtao Zhong, Bin Zhao, Guoda Ma, You Li,

https://doi.org/10.18632/aging.102211 pp 6569—6583

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Role and mechanism of cardiac insulin resistance in occurrence of heart failure caused by myocardial hypertrophy

Liling Zheng, Bingbing Li, Sihuang Lin, Liangcai Chen, Hongmu Li,

https://doi.org/10.18632/aging.102212 pp 6584—6590

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Research Perspective

In silico clinical trials for anti-aging therapies

Javier A. Menendez, Elisabet Cuyàs, Núria Folguera-Blasco, Sara Verdura, Begoña Martin-Castillo, Jorge Joven, Tomás Alarcón,

https://doi.org/10.18632/aging.102180 pp 6591—6601

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Review

Pathophysiology of aged lymphatic vessels

Tongyao Shang, Jiangjiu Liang, Carolyn M. Kapron, Ju Liu,

https://doi.org/10.18632/aging.102213 pp 6602—6613

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