The cover feature Figure 2 "Regional Manhattan plots and inter-CpG correlations for the top four genes identified in the global meta-analysis" from Lee et al. Aging devoted the Cover to a special roundtable discussion involving Dr. Yunsung Lee, Dr. Anil P.S. Ori, Dr. Ake T. Lu, and Dr. Steve Horvath talking about the connections between two papers published in current issue “Epigenome-wide association study of leukocyte telomere length” and “DNA methylation-based estimator of telomere length"
Yunsung Lee, Dianjianyi Sun, Anil P.S. Ori, Ake T. Lu, Anne Seeboth, Sarah E. Harris, Ian J. Deary, Riccardo E. Marioni, Mette Soerensen, Jonas Mengel-From, Jacob Hjelmborg, Kaare Christensen, James G. Wilson, Daniel Levy, Alex P. Reiner, Wei Chen, Shengxu Li, Jennifer R. Harris, Per Magnus, Abraham Aviv, Astanand Jugessur, Steve Horvath,
Lee Y, Sun D, Ori AP, Lu AT, Seeboth A, Harris SE, Deary IJ, Marioni RE, Soerensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, et al, . Epigenome-wide association study of leukocyte telomere length. . 11:5876-5894. https://doi.org/10.18632/aging.102230
Ake T. Lu, Anne Seeboth, Pei-Chien Tsai, Dianjianyi Sun, Austin Quach, Alex P. Reiner, Charles Kooperberg, Luigi Ferrucci, Lifang Hou, Andrea A. Baccarelli, Yun Li, Sarah E. Harris, Janie Corley, Adele Taylor, Ian J. Deary, James D. Stewart, Eric A. Whitsel, Themistocles L. Assimes, Wei Chen, Shengxu Li, Massimo Mangino, Jordana T. Bell, James G. Wilson, Abraham Aviv, Riccardo E. Marioni, Kenneth Raj, Steve Horvath,
Lu AT, Seeboth A, Tsai P, Sun D, Quach A, Reiner AP, Kooperberg C, Ferrucci L, Hou L, Baccarelli AA, Li Y, Harris SE, Corley J, et al, . DNA methylation-based estimator of telomere length. . 11:5895-5923. https://doi.org/10.18632/aging.102173
Camilo Toledo, Claudia Lucero, David C. Andrade, Hugo S. Díaz, Karla G. Schwarz, Katherin V. Pereyra, Alexis Arce-Álvarez, Nicolás A. López, Milka Martinez, Nibaldo C. Inestrosa, Rodrigo Del Rio,
Toledo C, Lucero C, Andrade DC, Díaz HS, Schwarz KG, Pereyra KV, Arce-Álvarez A, López NA, Martinez M, Inestrosa NC, Del Rio R, . Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus. . 11:5924-5942. https://doi.org/10.18632/aging.102150
Zarnani K, Nichols TE, Alfaro-Almagro F, Fagerlund B, Lauritzen M, Rostrup E, Smith SM, . Discovering markers of healthy aging: a prospective study in a Danish male birth cohort. . 11:5943-5974. https://doi.org/10.18632/aging.102151
Li M, Li L, Zhang X, Zhao H, Wei M, Zhai W, Wang B, Yan Y, . LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. . 11:5992-6013. https://doi.org/10.18632/aging.102159
Luo Y, Shen D, Chen L, Wang G, Liu X, Qian K, Xiao Y, Wang X, Ju L, . Identification of 9 key genes and small molecule drugs in clear cell renal cell carcinoma. . 11:6029-6052. https://doi.org/10.18632/aging.102161
Zhou F, Geng J, Xu S, Meng Q, Chen K, Liu F, Yang F, Pan B, Yu Y, . FAM83A signaling induces epithelial-mesenchymal transition by the PI3K/AKT/Snail pathway in NSCLC. . 11:6069-6088. https://doi.org/10.18632/aging.102163
Liu H, Gu X, Wang G, Huang Y, Ju S, Huang J, Wang X, . Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancer. . 11:6089-6108. https://doi.org/10.18632/aging.102168
Zou C, Wang J, Huang X, Jian C, Zou D, Li X, . Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease. . 11:6109-6119. https://doi.org/10.18632/aging.102169
Wu Q, Yuan X, Bai J, Han R, Li Z, Zhang H, Xiu R, . MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice. . 11:6120-6133. https://doi.org/10.18632/aging.102171
Olga I. Kechko, Irina Yu. Petrushanko, Christopher S. Brower, Alexei A. Adzhubei, Alexey A. Moskalev, Konstantin I. Piatkov, Vladimir A. Mitkevich, Alexander A. Makarov,
Zheng Z, Xu D, Shi K, Chen M, Lu F, . Prognostic value of genome-wide DNA methylation patterns in noncoding miRNAs and lncRNAs in uveal melanomas. . 11:6153-6174. https://doi.org/10.18632/aging.102178
Daniel Moreno-Blas, Elisa Gorostieta-Salas, Alexander Pommer-Alba, Gabriel Muciño-Hernández, Cristian Gerónimo-Olvera, Luis Angel Maciel-Barón, Mina Konigsberg, Lourdes Massieu, Susana Castro-Obregón,
Li N, Ding H, Zhang P, Li Z, Liu Y, Wang P, . Attenuated BK channel function promotes overactive bladder in a rat model of obesity. . 11:6199-6216. https://doi.org/10.18632/aging.102182
Zhao L, Luo Y, Lew D, Liu W, Au L, Mok V, Shi L, , . Risk estimation before progression to mild cognitive impairment and Alzheimer’s disease: an AD resemblance atrophy index. . 11:6217-6236. https://doi.org/10.18632/aging.102184
He A, He S, Peng D, Zhan Y, Li Y, Chen Z, Gong Y, Li X, Zhou L, . Prognostic value of long non-coding RNA signatures in bladder cancer. . 11:6237-6251. https://doi.org/10.18632/aging.102185
Zhang Z, Zhan Y, Zhang F, Yu B, Ji Y, Zhou J, Bai Y, Wang Y, Wang L, Jing Y, Duan W, Sun C, Sun T, et al, . Prognostic value of preoperative hematological markers combined with molecular pathology in patients with diffuse gliomas. . 11:6252-6272. https://doi.org/10.18632/aging.102186
Wei C, Zhu M, Zhang P, Yang X, Wang L, Ying J, Luan W, Chen C, Liu J, Zhu M, Yang Y, Feng Z, Qi F, et al, . Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma. . 11:6273-6285. https://doi.org/10.18632/aging.102187
Li Y, Yang D, Chen P, Yin X, Sun J, Li H, Ren G, . Efficacy and safety of neoadjuvant chemotherapy regimens for triple-negative breast cancer: a network meta-analysis. . 11:6286-6311. https://doi.org/10.18632/aging.102188
Xuesi Dong, Ruyang Zhang, Jieyu He, Linjing Lai, Raphael N. Alolga, Sipeng Shen, Ying Zhu, Dongfang You, Lijuan Lin, Chao Chen, Yang Zhao, Weiwei Duan, Li Su, Andrea Shafer, Moran Salama, Thomas Fleischer, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Rui Wang, Johan Staaf, Åslaug Helland, Manel Esteller, Yongyue Wei, Feng Chen, David C. Christiani,
Dong X, Zhang R, He J, Lai L, Alolga RN, Shen S, Zhu Y, You D, Lin L, Chen C, Zhao Y, Duan W, Su L, et al, . Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma. . 11:6312-6335. https://doi.org/10.18632/aging.102189
Granzotto A, Bomba M, Castelli V, Navarra R, Massetti N, d’Aurora M, Onofrj M, Cicalini I, del Boccio P, Gatta V, Cimini A, Piomelli D, Sensi SL, . Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. . 11:6336-6357. https://doi.org/10.18632/aging.102191
Qin R, Zhu H, Wang F, Song M, Lin P, Xing Y, Zhang W, Zhong M, Wang Z, . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. . 11:6358-6370. https://doi.org/10.18632/aging.102192
Cai C, Min S, Yan B, Liu W, Yang X, Li L, Wang T, Jin A, . MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling. . 11:6371-6384. https://doi.org/10.18632/aging.102194
Huang G, Zeng Y, Cheng Q, Cheng H, Ruan Y, Yuan C, Chen Y, He W, Chen H, He J, . Low triiodothyronine syndrome is associated with hemorrhagic transformation in patients with acute ischaemic stroke. . 11:6385-6397. https://doi.org/10.18632/aging.102195
Zhou Z, Zhu Y, Liu Y, Yin Y, . Comprehensive transcriptomic analysis indicates brain regional specific alterations in type 2 diabetes. . 11:6398-6421. https://doi.org/10.18632/aging.102196
Yang J, Zhang Y, Song H, . A disparate role of RP11-424C20.2/UHRF1 axis through control of tumor immune escape in liver hepatocellular carcinoma and thymoma. . 11:6422-6439. https://doi.org/10.18632/aging.102197
Lang X, Zhang W, Song X, Zhang G, Du X, Zhou Y, Li Z, Zhang XY, . FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia. . 11:6440-6448. https://doi.org/10.18632/aging.102198
Li N, Qian S, Li B, Zhan X, . Quantitative analysis of the human ovarian carcinoma mitochondrial phosphoproteome. . 11:6449-6468. https://doi.org/10.18632/aging.102199
Chen P, Chen Y, Wu W, Chen L, Yang X, Zhang S, . Identification and validation of four hub genes involved in the plaque deterioration of atherosclerosis. . 11:6469-6489. https://doi.org/10.18632/aging.102200
Qi F, Zhang R, Chen J, Zhao F, Sun Y, Du Z, Bing D, Li P, Shao S, Zhu H, Chu H, . Down-regulation of Cav1.3 in auditory pathway promotes age-related hearing loss by enhancing calcium-mediated oxidative stress in male mice. . 11:6490-6502. https://doi.org/10.18632/aging.102203
Xu W, Xu Y, Wang J, Tian X, Wu J, Wan F, Wang H, Qu Y, Zhang H, Ye D, . Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma. . 11:6503-6521. https://doi.org/10.18632/aging.102206
Zhao P, Liu J, Wang C, Zhao W, Zhang Y, Gu H, Tu J, Wang J, Ning X, . Strict target blood pressure management for reducing the stroke risk according to 2017 ACC/AHA blood pressure guideline. . 11:6522-6534. https://doi.org/10.18632/aging.102207
Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N, . Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. . 11:6535-6554. https://doi.org/10.18632/aging.102208
Marco Malavolta, Serena Dato, Francesco Villa, Francesco De Rango, Francesca Iannone, Anna Ferrario, Anna Maciag, Elena Ciaglia, Antonio D'amato, Albino Carrizzo, Andrea Basso, Fiorenza Orlando, Mauro Provinciali, Paolo Madeddu, Giuseppe Passarino, Carmine Vecchione, Giuseppina Rose, Annibale A Puca,
Malavolta M, Dato S, Villa F, Rango FD, Iannone F, Ferrario A, Maciag A, Ciaglia E, D'amato A, Carrizzo A, Basso A, Orlando F, Provinciali M, et al, . LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. . 11:6555-6568. https://doi.org/10.18632/aging.102209
Chen L, Hu W, Li S, Yao S, Wang M, Chen X, Chen S, Deng F, Zhu P, Li K, Zhong W, Zhao B, Ma G, et al, . Genetic variants of ADAMTS7 confer risk for ischaemic stroke in the Chinese population. . 11:6569-6583. https://doi.org/10.18632/aging.102211
Zheng L, Li B, Lin S, Chen L, Li H, . Role and mechanism of cardiac insulin resistance in occurrence of heart failure caused by myocardial hypertrophy. . 11:6584-6590. https://doi.org/10.18632/aging.102212