Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer

Xuan Jing; Hongping Liang; Chonghua Hao; Li Hongxia; Xiangrong Cui

doi:doi:10.18632/aging.102250

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Research Paper Volume 11, Issue 18 pp 7442—7456

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer

Figure 8. FOXA1 expression is negatively regulated by DNA methylation. (A) Heatmap including BRCA PAM50 subtypes, ER status, and BRCA DNA methylation data from TCGA-BRCA were identified by the UCSC Xena browser. (B) DNA methylation patterns in different subtypes of breast cancer (cluster 1 to 5, the lowest to the highest). (C) The expression of FOXA1 in different BRCA DNA methylation clusters.