Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Qian Su; Peng Zhang; Dong Yu; Zhaodi Wu; Dandan Li; Fangfang Shen; Pengfei Liao; Guizhi Yin

doi:doi:10.18632/aging.102272

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This article is currently undergoing investigation.

Research Paper Volume 11, Issue 18 pp 7570—7586

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Figure 9. LIMK1 was verified as a direct target gene of miR-93. (A) Online software predicted the binding site of miR-93 and LIMK1; (B) Luciferase activity assay verified the targeting relationship between miR-93 and LIMK1; *P < 0.05 vs. the mimics-NC group.