Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice

Huimin Li; Xinhui Wang; Xinyue Lu; Hongxin Zhu; Sheng Li; Shiwei Duan; Xinzhi Zhao; Fuquan Zhang; Gil Alterovitz; Fudi Wang; Qiang Li; Xiao-Li Tian; Mingqing Xu

doi:doi:10.18632/aging.102275

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Research Paper Volume 11, Issue 18 pp 7620—7638

Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice

Figure 3. The network of top 30 interconnected genes in the turquoise (A) and blue (B) modules and predicted miRNAs from TargetScan and Microcosm. The hub genes are shown in red and miRNAs in light yellow. mRNA-miRNA interactions from TargetScan and Microcosm are shown in green and blue lines respectively. Yellow circles show the genes that are putatively regulated by miRNAs.