Research Paper Volume 11, Issue 23 pp 11268—11313

Figure 4. RXFP3 constellation, differential overexpression of RXFP3 indicates a role in DNA damage response. (A–C) The results from the bioinformatic analysis of 0.5 μg RXFP3-HA (Left, grey), and 5 μg RXFP3-HA overexpression (Right, orange) using (B) Gene Ontology through Enrichr [50]; (C) Wordcloud generation and (D) phrase frequency counting (WriteWords) of the words and noun-phrases extracted from Textrous! [54]. Here we see that a different overexpression level of RXFP3, indicates a different role of RXFP3, where with 0.5 μg RXFP3 we see a role in translation, and chromatin structure, while for 5 μg RXFP3 overexpression a role for DNA damage response and repair.