Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 11, Issue 23

15 December, 2019
pp 10783—11794

About the Cover

The cover features Figure 7 "Scheme of epigenetic and molecular mechanisms changed in 5XFAD mice induced by pharmacological inhibition of G9a/GLP by UNC0642 “ from Griñán-Ferré et al.

Explore This Issue

Editorials

CX3CL1 intracellular domain and adult neurogenesis

Marc R. Benoit, Manoshi Gayen, Riqiang Yan,

https://doi.org/10.18632/aging.102504 pp 10783—10785

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Enterococcus faecalis bacteremia: please do the echo

Anders Dahl, José M. Miro, Niels E. Bruun,

https://doi.org/10.18632/aging.102619 pp 10786—10787

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Why doesn’t high cholesterol hurt?

Julius L. Katzmann, Ulrich Laufs,

https://doi.org/10.18632/aging.102620 pp 10788—10790

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PCSK9 inhibition in high-risk patients

Laurien E. Zijlstra, Simon P. Mooijaart, J. Wouter Jukema,

https://doi.org/10.18632/aging.102621 pp 10791—10792

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Metformin turns off the metabolic switch of pancreatic cancer

Xavier Deschênes-Simard, Marie-Camille Rowell, Gerardo Ferbeyre,

https://doi.org/10.18632/aging.102622 pp 10793—10795

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Research Papers

IL-10 produces a dual effect on OGD-induced neuronal apoptosis of cultured cortical neurons via the NF-κB pathway

Hongbin Chen, Wei Lin, Peiqiang Lin, Mouwei Zheng, Yongxing Lai, Manli Chen, Yixian Zhang, Jianhao Chen, Xiaohui Lin, Longzai Lin, Quan Lan, Qilin Yuan, Ronghua Chen, Xinhong Jiang, Yingchun Xiao, Nan Liu,

https://doi.org/10.18632/aging.102411 pp 10796—10813

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Long noncoding RNA LINC00958 accelerates the proliferation and matrix degradation of the nucleus pulposus by regulating miR-203/SMAD3

Kunchi Zhao, Yang Zhang, Hongping Yuan, Mingming Zhao, Dongxu Zhao,

https://doi.org/10.18632/aging.102436 pp 10814—10825

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circ5912 suppresses cancer progression via inducing MET in bladder cancer

Yinjie Su, Zehu Du, Guanglei Zhong, Yiyao Ya, Junming Bi, Juanyi Shi, Luping Chen, Wen Dong, Tianxin Lin,

https://doi.org/10.18632/aging.102464 pp 10826—10838

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HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

Jianxu Chen, Jiandi Chen, Jiaxin Huang, Zhanyu Li, Yihang Gong, Baojia Zou, Xialei Liu, Lei Ding, Peiping Li, Zhiquan Zhu, Baimeng Zhang, Hui Guo, Chaonong Cai, Jian Li,

https://doi.org/10.18632/aging.102488 pp 10839—10860

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Glycolysis gene expression profilings screen for prognostic risk signature of hepatocellular carcinoma

Longyang Jiang, Lan Zhao, Jia Bi, Qiutong Guan, Aoshuang Qi, Qian Wei, Miao He, Minjie Wei, Lin Zhao,

https://doi.org/10.18632/aging.102489 pp 10861—10882

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Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer

Yunjie He, Siying Zhou, Fei Deng, Shujie Zhao, Wenquan Chen, Dandan Wang, Xiu Chen, Juncheng Hou, Jian Zhang, Wei Zhang, Li Ding, Jinhai Tang, Zuomin Zhou,

https://doi.org/10.18632/aging.102490 pp 10883—10901

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The long non-coding RNA SNHG12 promotes gastric cancer by activating the phosphatidylinositol 3-kinase/AKT pathway

Rui Zhang, Yuan Liu, Hui Liu, Wei Chen, Hui-Ning Fan, Jing Zhang, Jin-Shui Zhu,

https://doi.org/10.18632/aging.102493 pp 10902—10922

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Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice

Xiang-Yu Zheng, Yu-Dan Lv, Feng-Yan Jin, Xiu-Juan Wu, Jie Zhu, Yang Ruan,

https://doi.org/10.18632/aging.102495 pp 10923—10938

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Metabolically healthy obesity reduces the risk of Alzheimer’s disease in elders: a longitudinal study

Ling-Zhi Ma, Yu-Yuan Huang, Zuo-Teng Wang, Jie-Qiong Li, Xiao-He Hou, Xue-Ning Shen, Ya-Nan Ou, Qiang Dong, Lan Tan, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative,

https://doi.org/10.18632/aging.102496 pp 10939—10951

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Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990–2017: results from a global burden of disease study, 2017

Hui Sun, Ting-Ting Gong, Yu-Ting Jiang, Shuang Zhang, Yu-Hong Zhao, Qi-Jun Wu,

https://doi.org/10.18632/aging.102497 pp 10952—10991

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Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1

Kun Ren, Heng Li, Hui-Fang Zhou, Yin Liang, Min Tong, Lu Chen, Xi-Long Zheng, Guo-Jun Zhao,

https://doi.org/10.18632/aging.102498 pp 10992—11009

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Reactive oxygen species metabolism-based prediction model and drug for patients with recurrent glioblastoma

Nian Tan, Jianwei Liu, Ping Li, Zhaoying Sun, Jianming Pan, Wei Zhao,

https://doi.org/10.18632/aging.102506 pp 11010—11029

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Parity is associated with albuminuria and chronic kidney disease: a population-based study

Kan Sun, Diaozhu Lin, Qiling Feng, Feng Li, Yiqin Qi, Chulin Huang, Wanting Feng, Chuan Yang, Li Yan, Meng Ren,

https://doi.org/10.18632/aging.102507 pp 11030—11039

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Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells

Chao-Qun Wang, Chih-Yang Lin, Yuan-Li Huang, Shih-Wei Wang, Yan Wang, Bi-Fei Huang, Yu-Wei Lai, Shun-Long Weng, Yi-Chin Fong, Chih-Hsin Tang, Zhong Lv,

https://doi.org/10.18632/aging.102508 pp 11040—11053

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EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC

Yan Liu, Yehui Zhou, Kuo-Hsiang Huang, Ying Li, Xujie Fang, Li An, Feifei Wang, Qingfei Chen, Yunchao Zhang, Aihua Shi, Shuang Yu, Jingzhong Zhang,

https://doi.org/10.18632/aging.102510 pp 11054—11072

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Clinical and neuroimaging correlates among cohorts of cerebral arteriostenosis, venostenosis and arterio-venous stenosis

Jiayue Ding, Jingwei Guan, Gary Rajah, David Dornbos III, Weili Li, Zhongao Wang, Yuchuan Ding, Xunming Ji, Ran Meng,

https://doi.org/10.18632/aging.102511 pp 11073—11083

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α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice

Dan Li, Qianyu Liu, Xiuqiang Lu, Zhengqiu Li, Chunming Wang, Chung-Hang Leung, Yitao Wang, Cheng Peng, Ligen Lin,

https://doi.org/10.18632/aging.102512 pp 11084—11110

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Daily decrease of post-operative alpha-fetoprotein by 9% discriminates prognosis of HCC: A multicenter retrospective study

Pei-Yun Zhou, Chao-Ping Yang, Zheng Tang, Yong Yi, Wei-Ren Liu, Meng-Xin Tian, Jin-Long Huang, Wei Gan, Xi-Fei Jiang, Gao Liu, Han Wang, Chen-Yang Tao, Yuan Fang, Wei-Feng Qu, Cheng Zhou, Ruo-Yu Guan, Bao-Ye Sun, Yu-Fu Zhou, Shu-Shu Song, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Jian Zhou, Jia Fan, Guo-Zhong Gong, Ying-Hong Shi, Shuang-Jian Qiu,

https://doi.org/10.18632/aging.102513 pp 11111—11123

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JAK1 as a prognostic marker and its correlation with immune infiltrates in breast cancer

Bo Chen, Jianguo Lai, Danian Dai, Rong Chen, Xuan Li, Ning Liao,

https://doi.org/10.18632/aging.102514 pp 11124—11135

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Ninjurin2 overexpression promotes glioma cell growth

Li-Na Zhou, Ping Li, Shang Cai, Gang Li, Fang Liu,

https://doi.org/10.18632/aging.102515 pp 11136—11147

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Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway

Junxiang Yin, Megan Nielsen, Tanner Carcione, Shiping Li, Jiong Shi,

https://doi.org/10.18632/aging.102516 pp 11148—11156

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A twenty gene-based gene set variation score reflects the pathological progression from cirrhosis to hepatocellular carcinoma

Yan Lin, Rong Liang, Jiazhou Ye, Qian Li, Ziyu Liu, Xing Gao, Xuemin Piao, Rongyun Mai, Donghua Zou, Lianying Ge,

https://doi.org/10.18632/aging.102518 pp 11157—11169

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Identification of differentially expressed genes in non-small cell lung cancer

Ke Wang, Ruo Chen, Zhuan Feng, Yu-Meng Zhu, Xiu-Xuan Sun, Wan Huang, Zhi-Nan Chen,

https://doi.org/10.18632/aging.102521 pp 11170—11185

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Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer’s disease

WenJun Yu, ShengJun An, TieMei Shao, HongJun Xu, HongXu Chen, JunDa Ning, YongJie Zhou, XiQing Chai,

https://doi.org/10.18632/aging.102522 pp 11186—11201

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ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653

Yinjie Su, Weilian Feng, Guanglei Zhong, Yiyao Ya, Zehu Du, Juanyi Shi, Luping Chen, Wen Dong, Tianxin Lin,

https://doi.org/10.18632/aging.102525 pp 11202—11223

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Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas

Chao Yang, Yanli Tan, Shouwei Li, Junhu Zhou, Qixue Wang, Yunfei Wang, Yingbin Xie, Luyue Chen, Jie Li, Chuan Fang, Chunsheng Kang,

https://doi.org/10.18632/aging.102526 pp 11224—11243

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Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach

Bethany S. Hall, Yvonne A. Barnett, Jonathan J. Crofts, Nadia Chuzhanova,

https://doi.org/10.18632/aging.102527 pp 11244—11267

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The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage

Jaana van Gastel, Hanne Leysen, Paula Santos-Otte, Jhana O. Hendrickx, Abdelkrim Azmi, Bronwen Martin, Stuart Maudsley,

https://doi.org/10.18632/aging.102528 pp 11268—11313

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CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9

Qingqing He, Lifang Huang, Dong Yan, Junming Bi, Meihua Yang, Jian Huang, Tianxin Lin,

https://doi.org/10.18632/aging.102530 pp 11314—11328

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Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer

Hongyan Wang, Kaihua Liu, Zhexu Chi, Xihang Zhou, Guoping Ren, Ren Zhou, Yinyan Li, Xiuwen Tang, Xiu Jun Wang,

https://doi.org/10.18632/aging.102531 pp 11329—11346

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Risk of ischemic stroke in patients with hypertrophic cardiomyopathy in the absence of atrial fibrillation – a nationwide cohort study

Ting-Tse Lin, Yen-Ling Sung, Tsung-Yu Ko, Chih-Kuo Lee, Lian-Yu Lin, Jimmy Ji-Ming Juang, Cho-Kai Wu,

https://doi.org/10.18632/aging.102532 pp 11347—11357

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LINC00682 inhibits gastric cancer cell progression via targeting microRNA-9-LMX1A signaling axis

Xiaohong Zhang, Jian Li, Fan Li, Zhen Zhao, Li Feng,

https://doi.org/10.18632/aging.102533 pp 11358—11368

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Posttranscriptional regulation of AKT by circular RNA angiomotin- like 1 mediates chemoresistance against paclitaxel in breast cancer cells

Jian Ma, Ling Fang, Qi Yang, Steven Hibberd, William W. Du, Nan Wu, Burton B. Yang,

https://doi.org/10.18632/aging.102535 pp 11369—11381

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Young age at diagnosis is associated with better prognosis in stage IV breast cancer

Wei Liu, Xi-feng Xiong, Yu-zhen Mo, Wei-guang Chen, Mei Li, Rong Liang, Zhi-biao Zhang, Zhi Zhang,

https://doi.org/10.18632/aging.102536 pp 11382—11390

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Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-κB pathway

Weiwei Qin, Jing Li, Rongjia Zhu, Suhua Gao, Junfen Fan, Mingrong Xia, Robert Chunhua Zhao, Jiewen Zhang,

https://doi.org/10.18632/aging.102537 pp 11391—11415

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Dysregulation of pseudogene/lncRNA-hsa-miR-363-3p-SPOCK2 pathway fuels stage progression of ovarian cancer

Weiyang Lou, Bisha Ding, Guansheng Zhong, Chengyong Du, Weimin Fan, Peifen Fu,

https://doi.org/10.18632/aging.102538 pp 11416—11439

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Prognostic implications of autophagy-associated gene signatures in non-small cell lung cancer

Yang Liu, Ligao Wu, Haijiao Ao, Meng Zhao, Xue Leng, Mingdong Liu, Jianqun Ma, Jinhong Zhu,

https://doi.org/10.18632/aging.102544 pp 11440—11462

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LncRNA EPIC1 downregulation mediates hydrogen peroxide-induced neuronal cell injury

Jian Sun, Jinyu Zheng, Ya Li, Ming Yan, Ping Li, Lili Ma,

https://doi.org/10.18632/aging.102545 pp 11463—11473

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Prognostic value of immune-related genes in clear cell renal cell carcinoma

Bangbei Wan, Bo Liu, Yuan Huang, Gang Yu, Cai Lv,

https://doi.org/10.18632/aging.102548 pp 11474—11489

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Conditional disease-free survival in high-risk renal cell carcinoma treated with sunitinib

Ning Shao, Hengchuan Su, Dingwei Ye,

https://doi.org/10.18632/aging.102549 pp 11490—11503

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Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy

Jilong Zhou, Zhouyiyuan Xue, Hai-Nan He, Xin Liu, Shu-Yuan Yin, Dan-Ya Wu, Xia Zhang, Heide Schatten, Yi-Liang Miao,

https://doi.org/10.18632/aging.102551 pp 11504—11519

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Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes

Qi Peng, Bin Chen, Hao Wang, Ying Zhu, Jinghong Wu, Yetao Luo, Guowei Zuo, Jinyong Luo, Lan Zhou, Qiong Shi, Yaguang Weng, Ailong Huang, Tong-Chuan He, Jiaming Fan,

https://doi.org/10.18632/aging.102552 pp 11520—11540

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The local translation of K_Na in dendritic projections of auditory neurons and the roles of K_Na in the transition from hidden to overt hearing loss

Jeong Han Lee, Mincheol Kang, Seojin Park, Maria C. Perez-Flores, Xiao-Dong Zhang, Wenying Wang, Michael Anne Gratton, Nipavan Chiamvimonvat, Ebenezer N. Yamoah,

https://doi.org/10.18632/aging.102553 pp 11541—11564

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Nrf2 activation mediates tumor-specific hepatic stellate cells-induced DIgR2 expression in dendritic cells

Yun-Hong Xia, Zhen Lu, Shou-Min Wang, Li-Xia Hu,

https://doi.org/10.18632/aging.102554 pp 11565—11575

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Robust immunoscore model to predict the response to anti-PD1 therapy in melanoma

Run-Cong Nie, Shu-Qiang Yuan, Yun Wang, Ying-Bo Chen, Yan-Yu Cai, Shi Chen, Shu-Man Li, Jie Zhou, Guo-Ming Chen, Tian-Qi Luo, Zhi-Wei Zhou, Yuan-Fang Li,

https://doi.org/10.18632/aging.102556 pp 11576—11590

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Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model

Christian Griñán-Ferré, Laura Marsal-García, Aina Bellver-Sanchis, Shukkoor Muhammed Kondengaden, Ravi Chakra Turga, Santiago Vázquez, Mercè Pallàs,

https://doi.org/10.18632/aging.102558 pp 11591—11608

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Long noncoding RNA NR2F1-AS1 enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p

Shenglong Li, Ke Zheng, Yi Pei, Wei Wang, Xiaojing Zhang,

https://doi.org/10.18632/aging.102563 pp 11609—11623

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Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin

Mei-Chi Chang, Yu-Hwa Pan, Hsyueh-Liang Wu, Yi-Jie Lu, Wan-Chuen Liao, Chien-Yang Yeh, Jang-Jaer Lee, Jiiang-Huei Jeng,

https://doi.org/10.18632/aging.102565 pp 11624—11639

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Specific DNA methylation markers in the diagnosis and prognosis of esophageal cancer

DaPeng Li, Lei Zhang, YuPeng Liu, HongRu Sun, Justina Ucheojor Onwuka, ZhiGang Zhao, WenJing Tian, Jing Xu, YaShuang Zhao, HongYu Xu,

https://doi.org/10.18632/aging.102569 pp 11640—11658

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Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

Hongrui Guo, Huan Liu, Zhijie Jian, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Weiming Lai, Zhengli Chen, Chao Huang,

https://doi.org/10.18632/aging.102570 pp 11659—11672

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Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease

Donghua Zou, Rongjie Li, Xiaohua Huang, Guoying Chen, Ying Liu, Youshi Meng, Yimei Wang, Yuan Wu, Yingwei Mao,

https://doi.org/10.18632/aging.102571 pp 11673—11685

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Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency

Cristina Ramos-Pérez, Margaret Dominska, Laura Anaissi-Afonso, Sara Cazorla-Rivero, Oliver Quevedo, Isabel Lorenzo-Castrillejo, Thomas D. Petes, Félix Machín,

https://doi.org/10.18632/aging.102573 pp 11686—11721

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Histone proteomics reveals novel post-translational modifications in breast cancer

Angela Mena Perri, Valter Agosti, Erika Olivo, Antonio Concolino, MariaTeresa De Angelis, Laura Tammè, Claudia Vincenza Fiumara, Giovanni Cuda, Domenica Scumaci,

https://doi.org/10.18632/aging.102577 pp 11722—11755

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Reviews

Adipose-derived stem cells contribute to cardiovascular remodeling

Hui Ni, Yiming Zhao, Yongli Ji, Jian Shen, Meixiang Xiang, Yao Xie,

https://doi.org/10.18632/aging.102491 pp 11756—11769

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Cancer stem cells-driven tumor growth and immune escape: the Janus face of neurotrophins

Viviana Triaca, Valentina Carito, Elena Fico, Pamela Rosso, Marco Fiore, Massimo Ralli, Alessandro Lambiase, Antonio Greco, Paola Tirassa,

https://doi.org/10.18632/aging.102499 pp 11770—11792

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Correction

Correction for: Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice

Luis Miguel Guachalla, Zhenyu Ju, Rafal Koziel, Guido von Figura, Zhangfa Song, Markus Fusser, Bernd Epe, Pidder Jansen-Dürr, K. Lenhard Rudolph,

https://doi.org/10.18632/aging.102602 pp 11793—11794

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