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Research Paper Volume 11, Issue 24 pp 12002—12031

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

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Figure 8. Role of circNF1-419 in regulated astrocyte and delay dementia. Circular RNA NF1-419 has autophagy enhancing activity by binding Dynamin-1 and AP2B1, delaying senile dementia by regulating aging markers (p21, p35/25, p16) and inflammatory factors (IL-6, IL-10, NF-κB), and by reducing the expression of AD marker proteins Tau, p-Tau, Aβ1-42, BACE1 and APOE.