The cover features Figure 14 "Wild-type mouse lenses in the B6 genetic background showed increased volume, nucleus size and overall stiffness, changes in cell morphology and microstructure along with appearance of anterior, cortical and ring cataracts with age. “ from Cheng et al.
Wang X, Peng L, Gong X, Zhang X, Sun R, . LncRNA HIF1A-AS2 promotes osteosarcoma progression by acting as a sponge of miR-129-5p. . 11:11803-11813. https://doi.org/10.18632/aging.102448
Yang Y, Yuan G, Xie H, Wei T, Zhu D, Cui J, Liu X, Shen R, Zhu Y, Yang X, . Circadian clock associates with tumor microenvironment in thoracic cancers. . 11:11814-11828. https://doi.org/10.18632/aging.102450
Tang L, Li J, Fu W, Wu W, Xu J, . Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo. . 11:11829-11843. https://doi.org/10.18632/aging.102452
Guan R, Cai Z, Wang J, Ding M, Li Z, Xu J, Li Y, Li J, Yao H, Liu W, Qian J, Deng B, Tang C, et al, . Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. . 11:11844-11864. https://doi.org/10.18632/aging.102454
Fu Q, Lu Z, Fu X, Ma S, Lu X, . MicroRNA 27b promotes cardiac fibrosis by targeting the FBW7/Snail pathway. . 11:11865-11879. https://doi.org/10.18632/aging.102465
Yang C, Zhang Y, Xu X, Li W, . Molecular subtypes based on DNA methylation predict prognosis in colon adenocarcinoma patients. . 11:11880-11892. https://doi.org/10.18632/aging.102492
Ding Z, Zhu H, Mo L, Li X, Xu R, Li T, Zhao L, Ren Y, Xu Y, Ou R, . FLT3L and granulocyte macrophage colony-stimulating factor enhance the anti-tumor and immune effects of an HPV16 E6/E7 vaccine. . 11:11893-11904. https://doi.org/10.18632/aging.102494
Xiong M, Zhuang K, Luo Y, Lai Q, Luo X, Fang Y, Zhang Y, Li A, Liu S, . KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway. . 11:11905-11921. https://doi.org/10.18632/aging.102505
Duan Y, Zhong Y, Song B, Zheng C, Xu K, Kong X, Li F, . Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes. . 11:11922-11936. https://doi.org/10.18632/aging.102509
Pan Z, Lin J, Wu D, He X, Wang W, Hu X, Zhang L, Wang M, . Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma. . 11:11937-11954. https://doi.org/10.18632/aging.102519
Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN, . Platelet-derived β2m regulates age related monocyte/macrophage functions. . 11:11955-11974. https://doi.org/10.18632/aging.102520
Kresovich JK, Xu Z, O’Brien KM, Weinberg CR, Sandler DP, Taylor JA, . Epigenetic mortality predictors and incidence of breast cancer. . 11:11975-11987. https://doi.org/10.18632/aging.102523
Mi B, Xiong Y, Chen L, Yan C, Endo Y, Liu Y, Liu J, Hu L, Hu Y, Sun Y, Cao F, Zhou W, Liu G, . CircRNA AFF4 promotes osteoblast cells proliferation and inhibits apoptosis via the Mir-7223-5p/PIK3R1 axis. . 11:11988-12001. https://doi.org/10.18632/aging.102524
Diling C, Yinrui G, Longkai Q, Xiaocui T, Yadi L, Xin Y, Guoyan H, Ou S, Tianqiao Y, Dongdong W, Yizhen X, Yang BB, Qingping W, . Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. . 11:12002-12031. https://doi.org/10.18632/aging.102529
Mo Y, Zhu J, Jiang A, Zhao J, Ye L, Han B, . Compound 13 activates AMPK-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation-reoxygenation. . 11:12032-12042. https://doi.org/10.18632/aging.102534
Xiao W, Zheng S, Zou Y, Yang A, Xie X, Tang H, Xie X, . CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1. . 11:12043-12056. https://doi.org/10.18632/aging.102539
Yang J, Shi S, Xu W, Qiu Y, Zheng J, Yu K, Song X, Li F, Wang Y, Wang R, Qu Y, Zhang H, Zhou X, . Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients. . 11:12057-12079. https://doi.org/10.18632/aging.102540
Duan J, Yin B, Li W, Chai T, Liang W, Huang Y, Tan X, Zheng P, Wu J, Li Y, Li Y, Zhou W, Xie P, . Age-related changes in microbial composition and function in cynomolgus macaques. . 11:12080-12096. https://doi.org/10.18632/aging.102541
Yao W, Guo A, Han X, Wu S, Chen C, Luo C, Li H, Li S, Hei Z, . Aerosol inhalation of a hydrogen-rich solution restored septic renal function. . 11:12097-12113. https://doi.org/10.18632/aging.102542
He R, Wang J, Ye K, Du J, Chen J, Liu W, . Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma. . 11:12114-12130. https://doi.org/10.18632/aging.102543
Li W, Deng G, Zhang J, Hu E, He Y, Lv J, Sun X, Wang K, Chen L, . Identification of breast cancer risk modules via an integrated strategy. . 11:12131-12146. https://doi.org/10.18632/aging.102546
Gao C, Gong Z, Wang D, Huang J, Qian Y, Nie M, Jiang W, Liu X, Luo H, Yuan J, Xiang T, An S, Quan W, et al, . Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p. . 11:12147-12164. https://doi.org/10.18632/aging.102550
Cheng Y, Xu T, Li S, Ruan H, . GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer. . 11:12165-12176. https://doi.org/10.18632/aging.102555
Du Y, Chen L, Jiao Y, Cheng Y, . Cerebrospinal fluid and blood Aβ levels in Down syndrome patients with and without dementia: a meta-analysis study. . 11:12202-12212. https://doi.org/10.18632/aging.102560
Wang JL, Luo X, Liu L, . Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production. . 11:12213-12235. https://doi.org/10.18632/aging.102561
Zhu L, Zhong Q, Yang T, Xiao X, . Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p. . 11:12236-12245. https://doi.org/10.18632/aging.102562
Wang Z, Gao L, Guo X, Feng C, Lian W, Deng K, Xing B, . Development and validation of a nomogram with an autophagy-related gene signature for predicting survival in patients with glioblastoma. . 11:12246-12269. https://doi.org/10.18632/aging.102566
Chen R, Chen Y, Huang G, Liu J, . Relationship between PD-L1 expression and 18F-FDG uptake in gastric cancer. . 11:12270-12277. https://doi.org/10.18632/aging.102567
Yu S, Zhang M, Huang L, Ma Z, Gong X, Liu W, Zhang J, Chen L, Yu Z, Zhao W, Liu Y, . ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling. . 11:12295-12314. https://doi.org/10.18632/aging.102572
Liu Y, Yang C, Zhao Y, Chi Q, Wang Z, Sun B, . Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis. . 11:12328-12344. https://doi.org/10.18632/aging.102575
Xiong Z, Zhou C, Wang L, Zhu R, Zhong L, Wan D, Wang Q, . Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO. . 11:12345-12360. https://doi.org/10.18632/aging.102576
Gao K, Liu M, Ding Y, Yao M, Zhu Y, Zhao J, Cheng L, Bai J, Wang F, Cao J, Li J, Tang H, Jia Y, et al, . A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway. . 11:12361-12374. https://doi.org/10.18632/aging.102578
Li Z, Lou Y, Tian G, Wu J, Lu A, Chen J, Xu B, Shi J, Yang J, . Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells. . 11:12375-12411. https://doi.org/10.18632/aging.102579
Liu J, Xue N, Guo Y, Niu K, Gao L, Zhang S, Gu H, Wang X, Zhao D, Fan R, . CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217/Wnt3 pathway. . 11:12412-12427. https://doi.org/10.18632/aging.102580
Yang H, Jiang Y, Zhang Y, Xu Y, Zhang C, Han J, Su F, Liu X, Mi K, Liu B, Shang D, . System level characterization of small molecule drugs and their affected long noncoding RNAs. . 11:12428-12451. https://doi.org/10.18632/aging.102581
Bai J, Liu Z, Liu J, Zhang S, Tian Y, Zhang Y, Ren L, Kong D, . Mitochondrial metabolic study guided by proteomics analysis in hepatocellular carcinoma cells surviving long-term incubation with the highest dose of sorafenib. . 11:12452-12475. https://doi.org/10.18632/aging.102582
Zhang Z, Liu J, Zeng Z, Fan J, Huang S, Zhang L, Zhang B, Wang X, Feng Y, Ye Z, Zhao L, Cao D, Yang L, et al, . lncRNA Rmst acts as an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by antagonizing Notch-targeting microRNAs. . 11:12476-12496. https://doi.org/10.18632/aging.102583
Catherine Cheng, Justin Parreno, Roberta B. Nowak, Sondip K. Biswas, Kehao Wang, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Juliet A. Moncaster, Woo-Kuen Lo, Barbara Pierscionek, Velia M. Fowler,
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H, . Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis. . 11:12532-12545. https://doi.org/10.18632/aging.102586
Li B, Li M, Li X, Li H, Lai Y, Huang S, He X, Si X, Zheng H, Liao W, Liao Y, Bin J, . Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation. . 11:12546-12567. https://doi.org/10.18632/aging.102587
Lei C, Peng X, Gong X, Fan Y, Wu S, Liu N, Li L, Huang J, Zheng G, Long Z, . Prognostic role of programmed death-ligand 1 expression in patients with biliary tract cancer: a meta-analysis. . 11:12568-12580. https://doi.org/10.18632/aging.102588
Qiu Q, Yu X, Yao C, Hao Y, Fan L, Li C, Xu P, An G, Li Z, He Z, . FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells. . 11:12581-12599. https://doi.org/10.18632/aging.102589
Namani A, Liu K, Wang S, Zhou X, Liao Y, Wang H, Wang XJ, Tang X, . Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways. . 11:12600-12623. https://doi.org/10.18632/aging.102590
Wu D, Zhang T, Wang J, Zhou J, Pan H, Qu P, . Long noncoding RNA NNT-AS1 enhances the malignant phenotype of bladder cancer by acting as a competing endogenous RNA on microRNA-496 thereby increasing HMGB1 expression. . 11:12624-12640. https://doi.org/10.18632/aging.102591
Zhang Y, Zhu W, He H, Fan B, Deng R, Hong Y, Liang X, Zhao H, Li X, Zhang F, . Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. . 11:12641-12660. https://doi.org/10.18632/aging.102592
Sun Q, Shen X, Wang P, Ma J, Sha W, . Targeting cyclophilin-D by miR-1281 protects human macrophages from Mycobacterium tuberculosis-induced programmed necrosis and apoptosis. . 11:12661-12673. https://doi.org/10.18632/aging.102593
Carrasco-Rios M, Ortolá R, Rodríguez-Artalejo F, García-Esquinas E, . Exposure to secondhand tobacco smoke is associated with reduced muscle strength in US adults. . 11:12674-12684. https://doi.org/10.18632/aging.102594
Luo Y, Xie Y, Zhang W, Lin Q, Tang G, Wu S, Huang M, Yin B, Huang J, Wei W, Yu J, Hou H, Mao L, et al, . Combination of lymphocyte number and function in evaluating host immunity. . 11:12685-12707. https://doi.org/10.18632/aging.102595
Song D, Deng Y, Liu K, Zhou L, Li N, Zheng Y, Hao Q, Yang S, Wu Y, Zhai Z, Li H, Dai Z, . Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies. . 11:12708-12732. https://doi.org/10.18632/aging.102597
Zhu Z, Yichen W, Ziheng Z, Dinghao G, Ming L, Wei L, Enfang S, Gang H, Honda H, Jian Y, . The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling. . 11:12733-12753. https://doi.org/10.18632/aging.102599
Zhu S, Min Z, Qiao X, Chen S, Yang J, Zhang X, Liu X, Ran W, Lv R, Lin Y, Wang J, . Expression profile-based screening for critical genes reveals S100A4, ACKR3 and CDH1 in docetaxel-resistant prostate cancer cells. . 11:12754-12772. https://doi.org/10.18632/aging.102600
Hao S, Yang W, . KIFC1 is essential for normal spermatogenesis and its depletion results in early germ cell apoptosis in the Kuruma shrimp, Penaeus (Marsupenaeus) japonicus. . 11:12773-12792. https://doi.org/10.18632/aging.102601
Gu Y, Ren K, Wang L, Yao Q, . Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice. . 11:12793-12809. https://doi.org/10.18632/aging.102603