Review Volume 11, Issue 24 pp 12827—12843

Figure 1. (A) Structure of human tau protein; Tau has an N-terminao projection region, a proline-rich domain(PRD), a microtubule-binding domain(MBD), and a C-terminal region. (B) Six isoforms of human tau. They differ by the inclusion of exon 2(NI), exon 3(N2), and exonlO(RI-R4).