Review Volume 11, Issue 24 pp 12844—12861

Figure 4. Improving immune system functions to efficiently remove senescent cells (1). A robust immune system targets senescent cells, leading to their removal (2). Then a regenerative process will maintain normal tissue functions (3). In situations where the immune system decays (e.g. immunosenescence or immunodepression), there will be an accumulation of senescent cells, increasing instability in the tissue/organ (4).