HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the <i>Axin1</i>-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Guangping Zhang; Luzhu Chen; Jing Liu; Yan Jin; Zaihong Lin; Shu Du; Zenghui Fu; Tuantuan Chen; Yinghui Qin; Fenghu Sui; Yan Jiang

doi:doi:10.18632/aging.102636

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Research Paper Volume 12, Issue 5 pp 4067—4081

HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Figure 2. The targeting relationship between Axin1 and miR-128-3p. (A) The binding sites between miR-128-3p and Axin1 3'UTR predicted by Targetscan (http://www.targetscan.org/vert_71/). (B) The targeting relationship between miR-128-3p and Axin1 verified using dual-luciferase reporter gene assay. In the X-axis, 3'UTR-Axin1-WT refers to Axin1 wild type 3’UTR and 3'UTR-Axin1-MUT refers to Axin1 mutant 3’UTR. * p < 0.05 vs. the control group (primary hippocampal neurons of normal mice). The experiment was repeated three times independently.