Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 12, Issue 5

15 March, 2020
pp 4045—4681

About the Cover

The cover features Figure 3 "Top 15 significant GO classes identified in the different cell types combining the results for the seven brain regions analyzed“ from Piras et al.

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Editorials

PoEMs edit breast cancer outcome

Pawel Bieniasz-Krzywiec, Massimiliano Mazzone,

https://doi.org/10.18632/aging.102870 pp 4045—4047

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Fasting for stem cell rejuvenation

Cristina González-Estévez, Ignacio Flores,

https://doi.org/10.18632/aging.102912 pp 4048—4049

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Transient and late-life rapamycin for healthspan extension

Ellen K. Quarles, Peter S. Rabinovitch,

https://doi.org/10.18632/aging.102947 pp 4050—4051

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Priority Research Paper

Survey of senescent cell markers with age in human tissues

M. Laura Idda, Waverly G. McClusky, Valeria Lodde, Rachel Munk, Kotb Abdelmohsen, Martina Rossi, Myriam Gorospe,

https://doi.org/10.18632/aging.102903 pp 4052—4066

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Research Papers

HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Guangping Zhang, Luzhu Chen, Jing Liu, Yan Jin, Zaihong Lin, Shu Du, Zenghui Fu, Tuantuan Chen, Yinghui Qin, Fenghu Sui, Yan Jiang,

https://doi.org/10.18632/aging.102636 pp 4067—4081

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Obstructive sleep apnea syndrome and causal relationship with female breast cancer: a mendelian randomization study

Xiao-Ling Gao, Zhi-Mei Jia, Fang-Fang Zhao, Dong-Dong An, Bei Wang, Er-Jing Cheng, Yan Chen, Jian-Nan Gong, Dai Liu, Ya-Qiong Huang, Jiao-Jiao Yang, Shu-Juan Wang,

https://doi.org/10.18632/aging.102725 pp 4082—4092

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Exosomal miR-19a from adipose-derived stem cells suppresses differentiation of corneal keratocytes into myofibroblasts

Ting Shen, Qingqing Zheng, Hongbo Luo, Xin Li, Zhuo Chen, Zeyu Song, Guanfang Zhou, Chaoyang Hong,

https://doi.org/10.18632/aging.102802 pp 4093—4110

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Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p

Yuanmin Zhang, Longfei Ma, Chengqun Wang, Lina Wang, Yanxia Guo, Guodong Wang,

https://doi.org/10.18632/aging.102839 pp 4111—4123

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ESHRD: deconvolution of brain homogenate RNA expression data to identify cell-type-specific alterations in Alzheimer’s disease

Ignazio S. Piras, Christiane Bleul, Joshua S. Talboom, Matthew D. De Both, Isabelle Schrauwen, Glenda Halliday, Amanda J. Myers, Geidy E. Serrano, Thomas G. Beach, Matthew J. Huentelman,

https://doi.org/10.18632/aging.102840 pp 4124—4162

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Reduced Ca²⁺ spark activity contributes to detrusor overactivity of rats with partial bladder outlet obstruction

Ji Zheng, Hao Zhou, Mengjun Yang, Siji Song, Qiang Dai, Guangju Ji, Zhansong Zhou,

https://doi.org/10.18632/aging.102855 pp 4163—4177

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SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity

Xiaojun Feng, Yanan Wang, Wenxu Chen, Suowen Xu, Lingli Li, Yadi Geng, Aizong Shen, Hui Gao, Lei Zhang, Sheng Liu,

https://doi.org/10.18632/aging.102862 pp 4178—4192

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Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes

Huan Yu, Hui Li, Xiaoqian Liu, Xiaoli Du, Binbin Deng,

https://doi.org/10.18632/aging.102873 pp 4193—4203

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Comprehensive characterization of endometrial competing endogenous RNA network in infertile women of childbearing age

Meihua Zhang, Junxia Li, Shuyin Duan, Zhenya Fang, Jiaqi Tian, Haoyu Yin, Qingfeng Zhai, Xietong Wang, Lin Zhang,

https://doi.org/10.18632/aging.102874 pp 4204—4221

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Identification of frailty-associated genes by coordination analysis of gene expression

Youwen Zhang, Ioulia Chatzistamou, Hippokratis Kiaris,

https://doi.org/10.18632/aging.102875 pp 4222—4229

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Development, validation and clinical impact of a prediction model for 6-month mortality in older cancer patients: the GRADE

Eurydice Angeli, Kader Chouahnia, Florence Canoui-Poitrine, Boris Duchemann, Thomas Aparicio, Elena Paillaud, Laurent Zelek, Guilhem Bousquet, Frédéric Pamoukdjian,

https://doi.org/10.18632/aging.102876 pp 4230—4246

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Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling

Wei Cai, Sanli Liu, Ziquan Liu, Shike Hou, Qi Lv, Huanhuan Cui, Xue Wang, Yuxin Zhang, Haojun Fan, Hui Ding,

https://doi.org/10.18632/aging.102878 pp 4247—4267

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GAA compound heterozygous mutations associated with autophagic impairment cause cerebral infarction in Pompe disease

Xiaodong Jia, Libin Shao, Chengcheng Liu, Tuanzhi Chen, Ling Peng, Yinguang Cao, Chuanchen Zhang, Xiafeng Yang, Guifeng Zhang, Jianlu Gao, Guangyi Fan, Mingliang Gu, Hongli Du, Zhangyong Xia,

https://doi.org/10.18632/aging.102879 pp 4268—4282

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Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome

Kangping Song, Xiaojie Liu, Qiuyue Zheng, Lingling Zhang, Hongying Zhang, Hailong Yu, Yan Zhu, Li-An Huang, Yingzhu Chen,

https://doi.org/10.18632/aging.102880 pp 4283—4298

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Transient ischemia-reperfusion induces cortical hyperactivity and AMPAR trafficking in the somatosensory cortex

Yuanyuan Li, Ran Ding, Feifei Wang, Cuiping Guo, Aili Liu, Liangpeng Wei, Shiyang Yuan, Feng Chen, Shaowei Hou, Zengguang Ma, Yan Zhang, Robert H. Cudmore, Xiaochuan Wang, Hui Shen,

https://doi.org/10.18632/aging.102881 pp 4299—4321

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Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition

Weibin Qian, Xinrui Cai, Qiuhai Qian,

https://doi.org/10.18632/aging.102882 pp 4322—4336

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Surgical blood loss during holmium laser enucleation of the prostate (HoLEP) is not affected by short-term pretreatment with dutasteride: a double-blind placebo-controlled trial on prostate vascularity

Gian Maria Busetto, Francesco Del Giudice, Martina Maggi, Gabriele Antonini, Daniele D’Agostino, Daniele Romagnoli, Alessandro Del Rosso, Marco Giampaoli, Paolo Corsi, Katie Palmer, Matteo Ferro, Giuseppe Lucarelli, Daniela Terracciano, Ottavio De Cobelli, Alessandro Sciarra, Ettore De Berardinis, Angelo Porreca,

https://doi.org/10.18632/aging.102883 pp 4337—4347

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Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Xiangbin Wang, Ding Ding, Qianhua Zhao, Xiaoniu Liang, Ling Peng, Xiaohu Zhao, Qian Xi, Zhang Min, Wei Wang, Xiaowen Xu, Qihao Guo, Pei-Jun Wang,

https://doi.org/10.18632/aging.102888 pp 4348—4356

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Elevated systemic inflammatory responses, factors associated with physical and mental quality of life, and prognosis of hepatocellular carcinoma

Yang Deng, Jian Zhu, Ziyi Liu, Maosheng Huang, David W. Chang, Jian Gu,

https://doi.org/10.18632/aging.102889 pp 4357—4370

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Vitamin D levels are prognostic factors for connective tissue disease associated interstitial lung disease (CTD-ILD)

Yujuan Gao, Qi Zhao, Xiaohua Qiu, Yi Zhuang, Min Yu, Jinghong Dai, Hourong Cai, Xin Yan,

https://doi.org/10.18632/aging.102890 pp 4371—4378

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Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease

Yang Wang, Qian Jiang, Hao Cai, Ze Xu, Wenjie Wu, Beilin Gu, Long Li, Wei Cai,

https://doi.org/10.18632/aging.102891 pp 4379—4393

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DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, Heterocephalus glaber

Robert Lowe, Amy F. Danson, Vardhman K. Rakyan, Selin Yildizoglu, Frédéric Saldmann, Melanie Viltard, Gérard Friedlander, Chris G. Faulkes,

https://doi.org/10.18632/aging.102892 pp 4394—4406

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Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer’s disease

Seong-Ho Koh, Seong Hye Choi, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Ju-Hee Kang, Jong-Min Lee, Hyun-Hee Park, Jungsoon Ha, Young Ju Suh, Suyeon Kang,

https://doi.org/10.18632/aging.102893 pp 4407—4423

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Discovery and validation of the prognostic value of the lncRNAs encoding snoRNAs in patients with clear cell renal cell carcinoma

Wuping Yang, Kenan Zhang, Lei Li, Kaifang Ma, Baoan Hong, Yanqing Gong, Kan Gong,

https://doi.org/10.18632/aging.102894 pp 4424—4444

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Distribution patterns of microsatellites and development of its marker in different genomic regions of forest musk deer genome based on high throughput sequencing

Wen-Hua Qi, Ting Lu, Cheng-Li Zheng, Xue-Mei Jiang, Hang Jie, Xiu-Yue Zhang, Bi-Song Yue, Gui-Jun Zhao,

https://doi.org/10.18632/aging.102895 pp 4445—4462

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Role of eotaxin-1/CCL11 in sepsis-induced myocardial injury in elderly patients

Ying Li, Youguang Zhao, Chenming Qiu, Yuanrui Yang, Guihua Liao, Xi Wu, Xiaowan Zhang, Qian Zhang, Ru Zhang, Zhang Wang,

https://doi.org/10.18632/aging.102896 pp 4463—4473

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Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

Ting Xin, Chengzhi Lu,

https://doi.org/10.18632/aging.102899 pp 4474—4488

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Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes

Munehiro Kitada, Yoshio Ogura, Itaru Monno, Jing Xu, Daisuke Koya,

https://doi.org/10.18632/aging.102902 pp 4489—4505

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LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Li-Li Sun, Feng-Rui Lei, Xu-Dong Jiang, Xiao-Long Du, Lun Xiao, Wen-Dong Li, Xiao-Qiang Li,

https://doi.org/10.18632/aging.102904 pp 4506—4526

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LncRNA-LALR1 upregulates small nucleolar RNA SNORD72 to promote growth and invasion of hepatocellular carcinoma

Lin-Hong Mao, Si-Yuan Chen, Xiao-Qin Li, Feng Xu, Jing Lei, Qing-Liang Wang, Li-Yang Luo, Hai-Yan Cao, Xin Ge, Tao Ran, Xue Li, Min Zou, Zhi-Hang Zhou, Xiao-Ling Wu, Song He,

https://doi.org/10.18632/aging.102907 pp 4527—4546

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ARV-825-induced BRD4 protein degradation as a therapy for thyroid carcinoma

Ling He, Chen Chen, Guoyu Gao, Kun Xu, Zhaoqun Ma,

https://doi.org/10.18632/aging.102910 pp 4547—4557

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Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1

Junrong Wang, Weimin Ding, Yingke Xu, Enfu Tao, Miaojun Mo, Wei Xu, Xu Cai, Xiaomin Chen, Junhui Yuan, Xiuying Wu,

https://doi.org/10.18632/aging.102911 pp 4558—4572

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APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma

Lei Cao, Hongwei Cheng, Qiuxia Jiang, Hui Li, Zhixian Wu,

https://doi.org/10.18632/aging.102913 pp 4573—4591

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Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study

Dmitry Kats, Kelly R. Evenson, Donglin Zeng, Christy L. Avery, Priya Palta, Stephen B. Kritchevsky, Gerardo Heiss,

https://doi.org/10.18632/aging.102916 pp 4592—4602

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The prognostic value of tumor mutational burden and immune cell infiltration in esophageal cancer patients with or without radiotherapy

Cheng Yuan, Liyang Xiang, Kuo Cao, Jianguo Zhang, Yuan Luo, Wenjie Sun, Nannan Zhang, Jiangbo Ren, Junhong Zhang, Yan Gong, Conghua Xie,

https://doi.org/10.18632/aging.102917 pp 4603—4616

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Alterations of hand sensorimotor function and cortical motor representations over the adult lifespan

Melina Hehl, Stephan P. Swinnen, Koen Cuypers,

https://doi.org/10.18632/aging.102925 pp 4617—4640

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Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models

Vanessa Castelli, Michele d’Angelo, Francesca Lombardi, Margherita Alfonsetti, Andrea Antonosante, Mariano Catanesi, Elisabetta Benedetti, Paola Palumbo, Maria Grazia Cifone, Antonio Giordano, Giovambattista Desideri, Annamaria Cimini,

https://doi.org/10.18632/aging.102927 pp 4641—4659

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Review

Adiponectin in renal fibrosis

Huan Jing, Simin Tang, Sen Lin, Meijuan Liao, Hongtao Chen, Youling Fan, Jun Zhou,

https://doi.org/10.18632/aging.102811 pp 4660—4672

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Research Perspective

The flip side of sirtuins: the emerging roles of protein acetyltransferases in aging

Prabakaran Nagarajan, Mark R. Parthun,

https://doi.org/10.18632/aging.102949 pp 4673—4677

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Corrections

Correction for: ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653

Yinjie Su, Weilian Feng, Guanglei Zhong, Yiyao Ya, Zehu Du, Juanyi Shi, Luping Chen, Wen Dong, Tianxin Lin,

https://doi.org/10.18632/aging.102885 pp 4678—4679

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Correction for: A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer’s-like pathology

Tingting Hu, Yue Zhou, Jing Lu, Peng Xia, Yue Chen, Xin Cao, Gang Pei,

https://doi.org/10.18632/aging.102898 pp 4680—4681

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