Research Paper Volume 12, Issue 10 pp 8837—8857
The TβR II-targeted aptamer S58 prevents fibrosis after glaucoma filtration surgery
Figure 8. Schematic diagram showing the mechanisms by which S58 promotes antioxidant defense of HConFs against fibrosis. S58 competitively binds to TβR II at the expense of TGF-β2 obviously accelerates the removal of ROS by activating the PI3K/Akt/Nrf2 signaling pathway and improves repair potential.