Research Paper Volume 12, Issue 10 pp 9066—9084
Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway
Figure 7. Downregulating TSLP inhibited the expression of inflammatory factors and JAK-STAT pathway biomarkers, which could be rescued by JAK-STAT signaling pathway activator. (A) The mRNA expression level of tumor necrosis factor (TNF)-α. (B) The mRNA expression level of interferon (IFN)-β. (C) The mRNA expression level of liver monocyte chemoattractant protein-1 (MCP1). (D) The mRNA expression level of IL-4. (E) The mRNA expression level of IL-6. (F) The expression level of TG in the liver. (G) The protein expression of the biomarkers of JAK-STAT signaling pathway. *P < 0.05; **P < 0.01, compared with WT group; #P < 0.05; ##P < 0.01, compared with NC group; &P < 0.05; &&P < 0.01, compared with sh-TSLP group. All data were means ± SD.