Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Hao Yang; Cheng Chen; Hao Chen; Xiaojun Duan; Juan Li; Yi Zhou; Weinan Zeng; Liu Yang

doi:doi:10.18632/aging.103177

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Research Paper Volume 12, Issue 13 pp 12750—12770

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Figure 6. Effect of ABT263 on OA chondrocytes in monolayer culture. (A) qPCR analysis of mRNA expression for MMP13, ADAMTS5, IL1β, IL6, COLII, ACAN and SOX9 at Day 3 and Day 10 separately. (B) Immunoblotting analysis of protein level for MMP13, ADAMTS5, IL1β, COLII, ACAN and SOX9 at Day 3 and Day 10 separately. Data are shown as mean ± standard deviation. N = 3 per group.