The cover features Figure 1 "A healthspan pathway map for humans, including the list of pathways/clusters with their labels as assigned by AutoAnnotate and their size (number of genes)“ from Möller et al.
Liu X, Zheng X, Liu B, Wu M, Zhang Z, Zhang G, Su X, . Serum IgM against SARS-CoV-2 correlates with in-hospital mortality in severe/critical patients with COVID-19 in Wuhan, China. . 12:12432-12440. https://doi.org/10.18632/aging.103417
Franny Jongbloed, Ron W.F. de Bruin, Harry Van Steeg, Piet Beekhof, Paul Wackers, Dennis A. Hesselink, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Jan N.M. IJzermans,
Jongbloed F, de Bruin RW, Steeg HV, Beekhof P, Wackers P, Hesselink DA, Hoeijmakers JH, Dollé ME, IJzermans JN, . Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients. . 12:12441-12467. https://doi.org/10.18632/aging.103619
Yu M, Ye Z, Chen Y, Qin T, Kou J, Tian D, Xiao F, . Questionnaire assessment helps the self-management of patients with inflammatory bowel disease during the outbreak of Coronavirus Disease 2019. . 12:12468-12478. https://doi.org/10.18632/aging.103525
Fan J, Hu K, Li X, Jiang Y, Zhou X, Gou X, Li X, . A qualitative study of the vocational and psychological perceptions and issues of transdisciplinary nurses during the COVID-19 outbreak. . 12:12479-12492. https://doi.org/10.18632/aging.103533
Fang X, Li S, Yu H, Wang P, Zhang Y, Chen Z, Li Y, Cheng L, Li W, Jia H, Ma X, . Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis. . 12:12493-12503. https://doi.org/10.18632/aging.103579
Gao S, Jiang F, Jin W, Shi Y, Yang L, Xia Y, Jia L, Wang B, Lin H, Cai Y, Xia Z, Peng J, . Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China. . 12:12504-12516. https://doi.org/10.18632/aging.103631
Daniel J. Wilkinson, Giovanny Rodriguez-Blanco, Warwick B. Dunn, Bethan E. Phillips, John P. Williams, Paul L. Greenhaff, Kenneth Smith, Iain J. Gallagher, Philip J. Atherton,
Wilkinson DJ, Rodriguez-Blanco G, Dunn WB, Phillips BE, Williams JP, Greenhaff PL, Smith K, Gallagher IJ, Atherton PJ, . Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing. . 12:12517-12533. https://doi.org/10.18632/aging.103513
Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Dirk Repsilber, Hans Jörgen Grabe, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Brecht Wouters, Liliane Schoofs, Walter Luyten, Georg Fuellen,
Arif Y, Spooner RK, Wiesman AI, Embury CM, Proskovec AL, Wilson TW, . Modulation of attention networks serving reorientation in healthy aging. . 12:12582-12597. https://doi.org/10.18632/aging.103515
Spitale FM, Vicario N, Rosa MD, Tibullo D, Vecchio M, Gulino R, Parenti R, . Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss. . 12:12598-12608. https://doi.org/10.18632/aging.103561
Nicola Alessio, Mustafa B. Acar, Ibrahim H. Demirsoy, Tiziana Squillaro, Dario Siniscalco, Giovanni Di Bernardo, Gianfranco Peluso, Servet Özcan, Umberto Galderisi,
Alessio N, Acar MB, Demirsoy IH, Squillaro T, Siniscalco D, Bernardo GD, Peluso G, Özcan S, Galderisi U, . Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice. . 12:12609-12621. https://doi.org/10.18632/aging.103606
Poulakis K, Ferreira D, Pereira JB, Smedby Ö, Vemuri P, Westman E, . Fully bayesian longitudinal unsupervised learning for the assessment and visualization of AD heterogeneity and progression. . 12:12622-12647. https://doi.org/10.18632/aging.103623
Ou H, Teng H, Qin Y, Luo X, Yang P, Zhang W, Chen W, Lv D, Tang H, . Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion. . 12:12669-12683. https://doi.org/10.18632/aging.102792
Lin H, You B, Lin X, Wang X, Zhou D, Chen Z, Chen Y, Wang R, . Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition. . 12:12684-12702. https://doi.org/10.18632/aging.103077
Cai B, Li M, Zheng Y, Yin Y, Jin F, Li X, Dong J, Jiao X, Liu X, Zhang K, Li D, Wang J, Yin G, . EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression. . 12:12726-12739. https://doi.org/10.18632/aging.103165
Zhang S, Yin Y, Li C, Zhao Y, Wang Q, Zhang X, . PAK4 suppresses TNF-induced release of endothelial microparticles in HUVECs cells. . 12:12740-12749. https://doi.org/10.18632/aging.103173
Yang H, Chen C, Chen H, Duan X, Li J, Zhou Y, Zeng W, Yang L, . Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis. . 12:12750-12770. https://doi.org/10.18632/aging.103177
Wang N, Jiang Y, Lv S, Wen H, Wu D, Wei Q, Dang Q, . HOTAIR expands the population of prostatic cancer stem-like cells and causes Docetaxel resistance via activating STAT3 signaling. . 12:12771-12782. https://doi.org/10.18632/aging.103188
Ren H, Luo J, Gao Y, Chen M, Chen X, Zhou H, Jiang Y, Zhang W, . Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications. . 12:12783-12798. https://doi.org/10.18632/aging.103213
Chu X, Yu T, Huang X, Xi Y, Ni B, Zhang R, You H, . Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats. . 12:12799-12811. https://doi.org/10.18632/aging.103222
Wu H, Liu C, Li X, Ji W, Xin C, Hu Z, Zhou L, . PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer. . 12:12812-12840. https://doi.org/10.18632/aging.103246
Zhang P, Song X, Dong Q, Zhou L, Wang L, . miR-27-3p inhibition restore fibroblasts viability in diabetic wound by targeting NOVA1. . 12:12841-12849. https://doi.org/10.18632/aging.103266
Fang H, Yang K, Tang P, Zhao N, Ma R, Luo X, Liu Q, . Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway. . 12:12850-12868. https://doi.org/10.18632/aging.103304
Wang Y, Song Y, Pang Y, Yu Z, Hua W, Gu Y, Qi J, Wu H, . miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression. . 12:12869-12895. https://doi.org/10.18632/aging.103343
Zhang Z, Weng W, Huang W, Wu B, Zhou Y, Zhang J, Deng T, Ye W, Zhang J, Ao J, Zhang Q, Shi K, . A novel molecular-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma. . 12:12896-12920. https://doi.org/10.18632/aging.103350
Wu C, Chen R, Xu L, Chen Y, Wang Y, Huang G, Liu J, . Relationship between the expression of oestrogen receptor and progesterone receptor and 18F-FDG uptake in endometrial cancer. . 12:12921-12929. https://doi.org/10.18632/aging.103352
Guo W, Chen X, Hao Y, Liu Q, Peng C, Zhao L, Feng Z, Wang X, Ruan H, Li L, . Efficacy and safety of an antithrombotic regimen for atrial fibrillation patients with acute coronary syndrome or those undergoing percutaneous coronary intervention: a meta-analysis. . 12:12930-12942. https://doi.org/10.18632/aging.103359
Dong H, Qiang Z, Chai D, Peng J, Xia Y, Hu R, Jiang H, . Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1. . 12:12943-12959. https://doi.org/10.18632/aging.103378
He D, Zhao F, Jiang H, Kang Y, Song Y, Lin X, Shi P, Zhang T, Pang X, . LOXL2 from human amniotic mesenchymal stem cells accelerates wound epithelialization by promoting differentiation and migration of keratinocytes. . 12:12960-12986. https://doi.org/10.18632/aging.103384
Wang H, Zhou Y, Yin Z, Chen L, Jin L, Cui Q, Xue L, . Transcriptome analysis of common and diverged circulating miRNAs between arterial and venous during aging. . 12:12987-13004. https://doi.org/10.18632/aging.103385
Liang X, Wang L, Wang M, Liu Z, Liu X, Zhang B, Liu E, Li G, . MicroRNA-124 inhibits macrophage cell apoptosis via targeting p38/MAPK signaling pathway in atherosclerosis development. . 12:13005-13022. https://doi.org/10.18632/aging.103387
Lin H, Kuei C, Lee H, Lin C, Zheng J, Chiu H, Chen C, Lin Y, . The Gαh/phospholipase C-δ1 interaction promotes autophagosome degradation by activating the Akt/mTORC1 pathway in metastatic triple-negative breast cancer. . 12:13023-13037. https://doi.org/10.18632/aging.103390
Yao Y, Wang X, Zhou D, Li H, Qian H, Zhang J, Jiang L, Wang B, Lin Q, Zhu X, . Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway. . 12:13059-13075. https://doi.org/10.18632/aging.103393
Zhou Y, Wu W, Cheng J, Liang L, Cen J, Chen C, Liu X, Xiong X, . CircFOXO3 rs12196996, a polymorphism at the gene flanking intron, is associated with circFOXO3 levels and the risk of coronary artery disease. . 12:13076-13089. https://doi.org/10.18632/aging.103398
Yang Y, Liu S, Wang Y, Wang Z, Ding W, Sun X, He K, Feng Q, Zhang X, . Changes of saliva microbiota in the onset and after the treatment of diabetes in patients with periodontitis. . 12:13090-13114. https://doi.org/10.18632/aging.103399
Guo M, Ma G, Zhang X, Tang W, Shi J, Wang Q, Cheng Y, Zhang B, Xu J, . ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling. . 12:13115-13127. https://doi.org/10.18632/aging.103400
Diao Y, Nie J, Tan P, Zhao Y, Zhao T, Tu J, Ji H, Cao Y, Wu Z, Liang H, Huang H, Li Y, Gao X, et al, . Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice. . 12:13128-13146. https://doi.org/10.18632/aging.103401
Li Z, Zhang W, Li C, Wang M, Wang S, Chen R, Zhang X, . Articulation rehabilitation induces cortical plasticity in adults with non-syndromic cleft lip and palate. . 12:13147-13159. https://doi.org/10.18632/aging.103402
Chen T, Zhao Z, Chen B, Wang Y, Yang F, Wang C, Dong Q, Liu Y, Liang H, Zhao W, Qi L, Xu Y, Gu Y, . An individualized transcriptional signature to predict the epithelial-mesenchymal transition based on relative expression ordering. . 12:13172-13186. https://doi.org/10.18632/aging.103407
Mei Z, Huang Y, Feng Z, Luo Y, Yang S, Du L, Jiang K, Liu X, Fu X, Deng Y, Zhou H, . Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway. . 12:13187-13205. https://doi.org/10.18632/aging.103420
Li F, Li C, Li X, Li Y, Zhong Y, Ling L, . Altered circular RNA expression profiles in the non-ischemic thalamus in focal cortical infarction mice. . 12:13206-13219. https://doi.org/10.18632/aging.103424
Chen C, Ling C, Gong J, Li C, Zhang L, Gao S, Li Z, Huang T, Wang H, Guo Y, . Increasing the expression of microRNA-126-5p in the temporal muscle can promote angiogenesis in the chronically ischemic brains of rats subjected to two-vessel occlusion plus encephalo-myo-synangiosis. . 12:13234-13254. https://doi.org/10.18632/aging.103431
Shi J, Liu C, Chen C, Guo K, Tang Z, Luo Y, Chen L, Su Y, Xu K, . Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis. . 12:13255-13280. https://doi.org/10.18632/aging.103432
Sun T, Bi F, Liu Z, Yang Q, . SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer. . 12:13281-13296. https://doi.org/10.18632/aging.103433
Tang D, Liu X, Chen K, Li Z, Dai Y, Xu J, Zhang H, Gao X, Liu L, . Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation. . 12:13297-13317. https://doi.org/10.18632/aging.103434
Han B, Zhang H, Zhu Y, Han X, Wang Z, Gao Z, Yuan Y, Tian R, Zhang F, Niu R, . Subtype-specific risk models for accurately predicting the prognosis of breast cancer using differentially expressed autophagy-related genes. . 12:13318-13337. https://doi.org/10.18632/aging.103437
Zhou P, Xie W, Huang H, Huang R, Tian C, Zhu H, Dai Y, Li Z, . circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway. . 12:13338-13353. https://doi.org/10.18632/aging.103438
Zhang Y, Liu C, Gao J, Shao S, Cui Y, Yin S, Pan B, . IL-22 promotes tumor growth of breast cancer cells in mice. . 12:13354-13364. https://doi.org/10.18632/aging.103439
Zhang X, Ye P, Huang H, Wang B, Dong F, Ling Q, . TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding. . 12:13365-13387. https://doi.org/10.18632/aging.103442
Liu Z, Li Y, Yu L, Chang Y, Yu J, . Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway. . 12:13400-13421. https://doi.org/10.18632/aging.103444
Wan L, Zhang Q, Luo H, Xu Z, Huang S, Yang F, Liu Y, Mahaman YAR, Ke D, Wang Q, Liu R, Wang J, Shu X, et al, . Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice. . 12:13422-13436. https://doi.org/10.18632/aging.103445
Shu X, Zhu H, Huang X, Yang Y, Wang D, Zhang Y, Zhang W, Ying Y, . Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment. . 12:13437-13462. https://doi.org/10.18632/aging.103446
Ru J, Guo L, Ji Y, Niu Y, . Hydrostatic pressure induces osteogenic differentiation of adipose-derived mesenchymal stem cells through increasing lncRNA-PAGBC. . 12:13477-13487. https://doi.org/10.18632/aging.103448
Zhang Q, Wang J, Liu M, Zhu Q, Li Q, Xie C, Han C, Wang Y, Gao M, Liu J, . Weighted correlation gene network analysis reveals a new stemness index-related survival model for prognostic prediction in hepatocellular carcinoma. . 12:13502-13517. https://doi.org/10.18632/aging.103454
Han L, Tang Y, Bai X, Liang X, Fan Y, Shen Y, Huang F, Wang J, . Association of the serum microRNA-29 family with cognitive impairment in Parkinson's disease. . 12:13518-13528. https://doi.org/10.18632/aging.103458
Ma J, Liu M, Wang Y, Xin C, Zhang H, Chen S, Zheng X, Zhang X, Xiao F, Yang S, . Quantitative proteomics analysis of young and elderly skin with DIA mass spectrometry reveals new skin aging-related proteins. . 12:13529-13554. https://doi.org/10.18632/aging.103461
Jarrell ZR, Smith MR, Hu X, Orr M, Liu KH, Quyyumi AA, Jones DP, Go Y, . Plasma acylcarnitine levels increase with healthy aging. . 12:13555-13570. https://doi.org/10.18632/aging.103462
Guo J, Wang Z, Fu M, Di J, Zha J, Liu J, Zhang G, Wang Q, Chen H, Tang P, Hou Z, Zhang Y, . Super elderly patients with intertrochanteric fractures do not predict worse outcomes and higher mortality than elderly patients: a propensity score matched analysis. . 12:13583-13593. https://doi.org/10.18632/aging.103466
Wang L, Nie Q, Gao M, Yang L, Xiang J, Xiao Y, Liu F, Gong X, Fu J, Wang Y, Nguyen QD, Liu Y, Liu M, et al, . The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression. . 12:13594-13617. https://doi.org/10.18632/aging.103474
Yang M, Li L, Chen S, Li S, Wang B, Zhang C, Chen Y, Yang L, Xin H, Chen C, Xu X, Zhang Q, He Y, et al, . Melatonin protects against apoptosis of megakaryocytic cells via its receptors and the AKT/mitochondrial/caspase pathway. . 12:13633-13646. https://doi.org/10.18632/aging.103483
Wang H, Tan L, Dong X, Liu L, Jiang Q, Li H, Shi J, Yang X, Dai X, Qian Z, Dong J, . MiR-146b-5p suppresses the malignancy of GSC/MSC fusion cells by targeting SMARCA5. . 12:13647-13667. https://doi.org/10.18632/aging.103489
Yang L, Wu B, Wu Z, Xu Y, Wang P, Li M, Xu R, Liang Y, . CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis. . 12:13668-13683. https://doi.org/10.18632/aging.103490
Liu W, Li C, Xu W, Liu X, Tang H, Huang H, . Genome-wide analyses of the prognosis-related mRNA alternative splicing landscape and novel splicing factors based on large-scale low grade glioma cohort. . 12:13684-13700. https://doi.org/10.18632/aging.103491
Zhang M, Zhang L, Li Y, Sun F, Fang Y, Zhang R, Wu J, Zhou G, Song H, Xue L, Han B, Zheng C, . Exome sequencing identifies somatic mutations in novel driver genes in non-small cell lung cancer. . 12:13701-13715. https://doi.org/10.18632/aging.103500
Fischer M, Ruhnau J, Schulze J, Obst D, Flöel A, Vogelgesang A, . Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo. . 12:13716-13739. https://doi.org/10.18632/aging.103527
Hadanny A, Daniel-Kotovsky M, Suzin G, Boussi-Gross R, Catalogna M, Dagan K, Hachmo Y, Abu Hamed R, Sasson E, Fishlev G, Lang E, Polak N, Doenyas K, et al, . Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial. . 12:13740-13761. https://doi.org/10.18632/aging.103571
Dong S, Liu P, Luo Y, Cui Y, Song L, Chen Y, . Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage. . 12:13791-13802. https://doi.org/10.18632/aging.103511
Semeraro MD, Smith C, Kaiser M, Levinger I, Duque G, Gruber H, Herrmann M, . Physical activity, a modulator of aging through effects on telomere biology. . 12:13803-13823. https://doi.org/10.18632/aging.103504
Gómez-Oliva R, Geribaldi-Doldán N, Domínguez-García S, Carrascal L, Verástegui C, Nunez-Abades P, Castro C, . Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling. . 12:13824-13844. https://doi.org/10.18632/aging.103510